Jia-Wey Shiau-Yau San (JWSYS), one of the traditional Chinese herbal formulas, is a famous herbal remedy used for the treatment of various menopause-related symptoms and stress-related neuropsychiatric disorders in Korea, Japan and China. Despite the wide use in clinical applications, the scientific literature on efficacy and safety of JWSYS is not available. The present study is a clinical research to evaluate the drug-use patterns of Chinese herbal medicine JWSYS in Taiwan during 2009.The National Health Insurance Research Database (NHIRD) was applied in this study. The Traditional Chinese Medical (TCM) database, a subset database of NHIRD, is the first national population TCM database, including of TCM ambulatory care expenditures by visits and details of TCM ambulatory care orders. The principal diagnosis was based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9CM) code. Patients took Jia-Wei-Xiao-Yao powder in 2009 was selected for the study subjects. In a 2009 statistics, it is revealed that a total of 899,712 persons had took JWSYS, and the total prescription number is 2,479,09 times. The age distribution of the 889,712 patients showed that most (30.44%) were between 36 and 50 years of age, and 27.63% were between 21 and 35. In addition, in gender the number of females who take JWSYS is greater than that of males, the ratio is about 4:1 (80.50%:19.50%). As for the top 10 major diseases treated by JWSYS, according to the statistics classified by the Institute with ICD-9 codes, they are different for males and females. The disease treated most with JWSYS for males is disorders of menstruation and other abnormal bleeding from female genital tract (ICD-9:626.9), while for males is sleep disturbances (ICD-9: 780.5). Within the top ten diseases of males and females, five major diseases are the same, including the sleep disorders, contact dermatitis, allergic rhinitis, migraine, and endocrine disorders, and the other remaining five major diseases are not the same. Although our survey tends tio indicate that JWSYS is the most commonly Chinese medicine prescribed in Taiwan of menstruation in female and for sleep disturbances in males, the efficacy and the therapeutic mechanisms of JWSYS in treating disorders of menstruation and sleep disturbances warrant further exploration in future studies.