Preeclampsia is the most common & major medical complication of pregnancy with a high incidence of national health problem & also responsible for high maternal & fetal morbidity & mortality1,2. In preeclampsia there is an abnormally increase in the lipid peroxidation in maternal blood and also in normal pregnancy3.4. But serum antioxidants are significantly decreased that lead to pathogenesis of preeclampsia5,6. For this, the study was undertaken to assess the lipid peroxidation product, serum Malondialdiehyde(MDA) & antioxidant (vitamin-E)levels in women with preeclampsia as well as in normal pregnancy.The study was conducted on 40 pregnant women(Group-B as study group) age ranged from 25 to 35 years in the Department of Biochemistry, Budi Kemuliaan Maternity Hospital( BKMH) in Jakarta in the year of 2006. The study group was further divided into B1-(normal pregnant women) & B2(preeclamptic patient).For comparison age matched 20 apparently healthy non pregnant women (Group-A as control group)was also included in the study. The study subjects were selected from outpatient department (OPD) of Obstetrics & Gynaecology of BKMH in Jakarta. The ethical permission was taken from Ethical Review Committee of BKMH, Jakarta. Serum MDA (lipid peroxidation product) was measured by Thiobarbituric acid reactive substances assay (TBRAS) method & vit-E was estimated Spectrophotometrically. Data were analyzed statistically by ANOVA test among the groups and unpaired Students “t” test between the groups by using SPSS. The mean serum MDA levels were (1.23+ 0.5, 3.64 + 0.12, 7.28 +1.05 mmol/ml) and vitamin E levels were (7.43 +1 40, 5.75 + 1.24, 2.69 +0.17 micro mole/L) in group A, B1, and B2 respectively. However, MDA levels were significantly (p<0.001) higher in preeclampsia than those of normal pregnant women. Again the serum MDA levels were significantly (p<0.001) higher in both the study groups than that of nonpregnant control group. But the serum vit-E level were significantly (p<0.001) lower in preeclampsia than those of normal pregnant women as well as control group. This results revealed that lipid peroxidation is an important factor in the pathogenesis of preeclampsia. In preeclamptic patients serum antioxidants are excessively utilized to counteract the cellular changes mediated by free radicals7.