Changes in lung diffusing capacity for carbon monoxide (DLCO) are linked to aerobic performance and lung interstitial disease (1-2), both at sea level (SL) (3) and high-altiude (HA) (4). The aim of this study is to evaluate the changes in lung diffusion capacity for carbon monoxide (DLCO) produced after anaerobic and aerobic exercise at SL and after a rapid exposure and exercise at HA. The participants were 10 healthy active subjects (7 females and 3 males) aged 21 to 26. A study of DLCO was developed under different conditions: The first day, DLCO was obtained basal at SL, post-maximal 30-s exercise at SL (SL-ANA), and post-moderate exercise at SL (SL-ANA). The second day, DLCO was obtained basal at SL, basal at 4,000 m of altitude (HA-R) and post-moderate exercise at 4,000 m (HA-AER). The method used to evaluate DLCO was the single-breath method in a computerized spirometer. There was an increase in DLCO after 30-s maximal exercise at SL. Also there was a direct correlation in basal DLCO at SL and Watts developed during 30-s maximal exercise (R=0.95). Then DLCO was reduced after aerobic exercise at SL. During HA exposure, there was no changes in DLCO or any other pulmonary structural or functional parameter, either after a rapid exposure to 4,000 m, or after moderate aerobic exercise. Large increases in DLCO can occur acutely after anaerobic 30-s maximal exercise in a cycle ergometer. An acute exposure to HA does not elicit any change neither at rest nor at exercise. Therefore exercise intensity may be the most important factor to elicit modifications in lung diffusing capacity.
Future Physiology 2020 (Virutal) (2020) Proc Physiol Soc 46, PC0091
Poster Communications: Lung diffusing response to exercise at sea level and high-altitude
Iker García Alday1, 2, Franchek Drobnic3, Yinkiria Cheng4, 5, Victoria Pons1, Casemiro Javierre6, Ginés Viscor2
1 Centro de Alto Rendimiento (CAR), Av. Alcalde Barnils s/n, 08173 , Sant Cugat Del Valles, Spain 2 Physiology Section, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain 3 Medical Services Shenhua Greenland FC, Shanghai, China 4 Departamento de Fisiología y Comportamiento Animal, Facultad de Biología, Universidad de Panamá, Ciudad de Panamá, Panama 5 Centro de Estudios de Recursos Bioticos (CEREB), Ciudad de Panamá, Panama 6 Exercise Physiology Unit, Department of Physiological Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain
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Where applicable, experiments conform with Society ethical requirements.