Background The pancreas is an organ which secrets digestive juices for digestion of food. It harbours Islets of Langerhans which secret insulin for maintaining blood sugar levels. Pancreatic cancer is an aggressive cancer. Surgery to remove the cancer improves survival. However a third of patients with pancreatic cancer have the fear of increased complications after surgery. Resection (removing part of pancreas) has been suggested but to the best of our knowledge randomized controlled trials done so far have not given any conclusion. Materials and Method: Fourty Wistar rats were used in two phases. The two phases were the same procedure but in addition phase two rats were given 1000mg/kg of vitamin C as primer before and after the surgery. Each phase had four groups of five rats each. Groups 1-3 had resection done as follows: one quarter (¼), half (½), three quarter (¾) resection of pancreas while group 4 served as control. Rats were anesthetized with 90mg/kg ketamine and 10mg/kg Xylazine. Midline laparotomy incision was made on the lineal alba to expose the contents of abdominal cavity. One quarter, half and three quarter of each pancreas was excised without interfering with the pancreatic duct. The duodenal loop was then returned back into the abdominal cavity. Linea alba was closed with 5-0 chromic catgut using simple continuous suture pattern while the skin was closed with 5-0 nylon using simple interrupted suture pattern. Results: First two weeks our report showed 100% survival of ¼ resection group in both phases, 40% of survival of ½ resection group and 100% mortality of ¾ resection group in the non-vitamin C supplemented phase. There was 80% survival of (½) resection group and 60% survival (¾) resection group in the vitamin C supplemented group. Our ECG result showed no significant difference in heart rate of all groups in ‘P’, PR, QRS after two weeks of resection but QTc in ¾ resection was significantly higher than the other groups. Blood glucose level checked every day post operation remained within normal range in all the groups. Serum cortisol level was significantly higher in ¾ group (33.959± 1.04) ng/ml than ½ (18.49± 0.66) ng/m, ¼ (22.409±1.02) ng/ml and control (16.88±0.97) ng/ml of the vitamin c group. No significant difference was seen in T3 values of ¾ and ½ but the two were insignificantly higher than ¼ and control groups. No significant difference was observed in the T4 of all the groups. Discussion and conclusion: Vitamin C is a strong antioxidant that can strengthen body’s natural defenses that boost the immune system. It protects cells from free radicals, encourage the production of white blood cells. It also helps these wbc function more effectively while protecting cell from damage by potentially harmful molecules. Studies have also shown that vitamin C may shorten wound healing time. Conclusively, vitamin C could offer longevity to the life of pancreatomiced individual regardless of the size of the pancreas resected.