Abnormalities of microcirculation occur in multiple tissue beds in patients with cardiovascular diseases (CVDs) and lead to end-organ damage. It is known that high levels of inflammatory markers in CVDs patients were found. The purpose of our study was to estimate whether micro vascular disorders correlates with level of inflammatory markers. In patients with coronary artery disease CAD (n=37; male: 23; mean age: 62,7±6) and chronic heart failure (CHF) (n=33; male: 20; mean age: 58,2±7,5) New York Heart Association (NYHA) class II -III and 34 healthy controls (male: 17; mean age: 57,3± 7,9) digital photoplethysmography and nail fold videocapillaroscopy at resting baseline, during venous occlusion were performed. We evaluated structural changes of microcirculation in small resistance arteries (reflection index, RI) and diameters of arterial (Da) and venous (Dv) part of capillary loop. Endothelial function (occlusion index, IO) of arterioles and capillary function (percent capillary recruitment, pCR) (Cheng C et al. (2008). Ther Adv Cardiovasc Dis. 2(2), 79-88) were estimated. Inflammatory markers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen were determined. Values are median and IQI, compared by Mann-Whitney U-test. Correlation was estimated by Spearman’s Rank Correlation Coefficient (rs). In patients with CAD and CHF structural and functional of microcirculation in arterioles were found. IO in CAD and CHF patients was significantly different from controls (IO CAD: 1,6 (1,4;1,9) vs. CHF: 1,5 (1,3;1,7) vs. control: 1,8 (1,5;2,7); p<0.05). Structural changes in arterioles level (RI) were above norm (< 30%), in all groups but there was no different RI between groups (RI CAD 37,2 (22,3;47,5) vs. CHF 32,2 (25,3;47,2) vs. Control: 33,5 (29,5;47) , p= 0.3). Functional disorders of capillary (pCR) in patients with CAD and CHF were found. pCR was significantly lower in CVDs groups than in controls, while there was no differences between CAD and CHF groups (pCR CAD: 90 (82;93) vs. CHF: 88 (75;95) vs. control: 93 (88;96), p<0.05). Da was significantly lower in CAD patients than controls (Da CAD: 5.2 (4.9;5.5) vs. control 7.1 (7.0;9.5), p<0.05). Dv was higher in CHF patients (Dv CHF: 13.7 (10.5;17) vs. control 2.1 (10.8;14.6), p<0.05), while there was no differences between CAD and control. Correlation between Da and CRP (rs = 0,34; p<0.05), Da and fibrinogen (rs = -0,28; p<0.05) were found. Dv correlated with ESR (rs = -0,23; p<0.05). This data show that abnormalities of microcirculation in capillary level correlate with levels of inflammatory markers in patients with coronary artery decease and chronic heart failure. It might be that micro vascular disorders are also occurs via mechanisms of inflammation.