Introduction: OT is a simple, non invasive and reproducible test which allows the stimulation of the Autonomic Nervous System (ANS) and its exploration by measuring the BP and the HR variation during the upright posture. We aimed to describe the orthostatic test (OT) in diabetic patient and compare it with that of healthy subjects. Patients and Methods: This cross-sectional case-control study included consecutive 20 diabetic patients suffering from type 2 diabetes (mean age 54.6±7.6 years with extremes ranging from 31 to 72 years; duration of diabetes 48 [3, 240] months, 80% women ) without degenerative complications which could interfere with ANS and 42 healthy subjects ( mean age 53.5± 8.4 years with extremes ranging from 33 to 75 years, 81% women). The Medical research ethics comity of the faculty of medicine of Rabat approved the study, and all participants provided written consent. The two groups were matched for age (p = 0.57) and sex (p = 0.99). The basal BP and HR were measured at rest in both arms, every 5 minutes during at least 30 minutes. We then, proceeded to OT. We choose to measure HR and orthostatic SBP during upright posture of the rhythm of 3 measurements per minute during 10 minutes. The variations of the orthostatic HR (providing information on adrenergic alpha sympathic activity impaired sympathic if decrease more than 10 and sympathic hyperreactivity if increase superior to 17) and orthostatique SBP (providing information on adrenergic beta sympathic activity: orthostatic hypotension if decrease more than 20 and orthostatic hypertension if increase superior to 10) were compared between the diabetic patients and the healthy subjects using the Student’s t-test for and the χ2 test. Results : Diabetic patients have significantly more sympathic hyperreactivity than heathy controls (table 1). Conclusion: This study suggests that diabetics tend to have a sympathetic hyper-reactivity during an orthostatic test. These results should be confirmed by larger studies.