Emerging evidences have shown that shisha (water pipe tobacco) smoking is associated with higher exposure to carbon monoxide and nicotine than cigarette.1 Despite these evidences, the prevalence and popularity of shisha smoking are rapidly increasing among youth globally including developing countries like Nigeria.1,2 Basic assessment of peripheral capillary oxygen saturation (SPO2), mean arterial pressure (MAP) and pulse rate in young chronic smokers is therefore necessary. The study was conducted at Nassarawa local government area of Kano state, Nigeria. 103 young (15 – 30 years) shisha smokers who have been smoking for 3 years or more with at least 1 session of smoking per day and with BMI of 19 – 24 kg/m2 were recruited and classified as group 1 (study group). Likewise, 100 young nonsmokers matched for age, BMI and living in the same environment with group 1 members were recruited as controls (group 2). Participants with known history of cigarette smoking, cardiovascular and respiratory diseases were excluded. Ethical clearance and approval with reference number MOH/Off/797/T.I/527 was obtained from Kano state Ministry of Health prior to the commencement of the study. SPO2 and pulse rate of the participants were assessed at rest and values were taken from middle finger using pulse oximeter. Blood pressure measurement was done at the same time using sphygmomanometer and MAP was estimated as MAP = Diastolic pressure + 1/3 pulse pressure. Values were expressed as Mean ± S.E.M and Data were analyzed with IBM SPSS Statistics for Windows version 23.0. Results were compared between the groups using independent sample t test. P values < 0.05 were considered statistically significant. SPO2 was found to be significantly lower (P < 0.05) among group 1 members (91.98 ± 0.42 %) compared to group 2 (97.94 ± 0.18%). The MAP and pulse rate obtained from group 1 (100.15 ± 0.78 mmHg and 91.32 ± 0.83b/min) were significantly higher (P < 0.05) compared to group 2 with MAP and pulse rate of (92.44 ± 0.79 mmHg and 79.19 ± 1.18b/min respectively). The study implies that shisha smoking is associated with risk of hypoxia, hypertension and tachycardia by causing decrease in SPO2, increase in MAP and increase in pulse rate.