Introduction: Circulatory changes during Valsalva Maneuver (VM) include venous congestion in the extra-thoracic regions with an associated rise in peripheral venous pressures (1). There is a scarcity of techniques available for non-invasively monitoring the circulatory changes in peripheral veins during VM. The magnitude of the DC component of Photoplethysmographic (PPG) signal which is dependent on the average blood volume in tissues (2) has been shown to correlate with the peripheral venous pressure measured invasively (3). We measured the shift in DC component of PPG at different expiratory pressures of VM with the hypothesis that increasing venous congestion associated with the graded increase in Valsalva pressure would produce a proportional shift in PPG DC component. Methods: Eleven healthy male volunteers (age range; 17 – 30 years) participated in the study. PPG signal was acquired from right middle finger using a reflection mode transducer at a sampling rate of 1 KHz along with air way pressure while the subject performed VM sequentially at different airway expiratory pressures of 10, 20, 30 and 40 mm Hg. DC component of PPG was extracted from the raw signal using a low pass filter of 0.5 Hz (3). The shift in the DC component was calculated as the difference between maximum signal level during VM at each pressure and the average signal level during the preceding baseline period corresponding to the duration of one respiratory cycle. Repeated measures ANOVA with post hoc Bonferroni’s test and Pearson univariate correlation analysis was done to statistically analyze the data. Results: A proportional rise was obtained in the PPG DC component shift with increase in Valsalva pressure (0.085 ± 0.063 Volts (V), 0.177 ± 0.112 V, 0.264 ± 0.139 V and 0.323 ± 0.152 V for VM conducted at 10, 20, 30 and 40 mm Hg pressure respectively). There was a statistically significant (p<0.05) increase in DC component shift with the increase in expiratory pressure from 10 to 20 and 20 to 30 mm Hg but not for the increment from 30 to 40 mm Hg. There was a significant positive correlation between the shifts in DC component and the corresponding Valsalva pressures (r = 0.99; p = 0.004). Conclusion: The results indicate that shift in PPG DC component during VM may be utilized as a tool to monitor the peripheral circulatory changes during VM. It may also be utilized as a parameter to check the correct performance of the maneuver by the subject as peripheral venous congestion would only accompany a properly conducted VM. The flattening of the response at higher pressures (30 to 40 mm Hg) probably indicates venous congestion approaching the capacitance limit of vessels.