INTRODUCTION The implantation and maintenance of Human pregnancy involves the immune system and the endocrine system; They regulate, communicate and interact closely by signal communication. Metabolic changes that result from physiological alterations at the boundary between mother and fetus, known as the FELO-PLACEMENTAL UNIT (FPU). This interface is a major site of protein and steroid hormone production and secretion. Many of the endocrine and metabolic changes that occur during pregnancy can be directly attributed to hormonal signals originating from FPU. Proper timing of these neuro-endocrine events within and between the placental, fetal and maternal compartments is critical in directing fetal growth and development as well as the coordinating the timing of parturition. The phosphatidyl inositol enzymes and other second messenger help in the communication and close interaction between the endocrine and the immune system. PRINCIPLE Signal communication between Hormonal receptors on the plasma membrane and the intracellular Ca2+ reservoir is accomplished by product of phosphatidylinositol metabolism thereby phosphatidylinositides are involved in all growth and signal transduction and are precursor to many other secondary messenger molecules involved in regulation of cellular activities. LABORATORY ANALYSIS 120 women used for this research were grouped into six of (20) viz spontaneous aborters, primary infertile, secondary infertile, (Test group). Multiparous, pregnant and non pregnant (control group). Antithyroid antibody test, Pi3k assay and Ca 2+ Assay were done. STATISTICAL ANALYSIS Data of the parameters were measured as mean ± standard error of mean values. Differences between mean values were analyse using the t test. P 0.05 were insignificant. CONCLUSION The unregulated increase in pi3k resulted into autoimmune disorder seen in the test sample, when mean of 72.3% failed Antithyroid antibody test. While means of 84% of the control sample passed the Antithyroid antibody tests. Therefore unregulated changes in Pi3k plays a critical role in modulating the metabolic and immunologic changes required for successful outcome in pregnancy.