The distribution, metabolism and excretion is of importance for all pharmacological active drugs. Non-invasive mapping of the drug injected is possible using the well known major imaging modalities: CT, PET, SPECT and MRI. While CT, and SPECT require labelling with a heavy atom (I, Tc) it is possible to label with F or C isotopes using PET and MRI. Using PET it is possible to map the fate of the injected F atom, but using MRI it is possible to map the molecules, as such, containing i.e. a C-13 label. The sensitivity of MRI is, however, low and extended use of C-13 spectroscopy has not taken place due to the low resolution (cm3) and long imaging times (many minutes). Recently methods to hyperpolarise the magnetic active nuclei have been introduced making it possible to perform in vivo metabolic MR imaging of some small endogeneous molecules, such as pyruvate and amino acids. It has been shown that Pyruvate and the metabolites lactate, alanine and bicarbonate can be mapped in a heart where ischemia have been introduced. Images will be shown where the high MRI proton resolution in animals have been superimposed on the metabolic images created after injecting pyruvate in rats and pigs. Flow and perfusion images were also created! The technique open possibilities for many interesting pharmacological studies, where the metabolism and the site for metabolism are important for the understanding of the new drug effect. Real molecular imaging has become a new important researh tool for pharmacological and physiological studies.