Repeated episodes of ischemia and reperfusion (I&R) applied to one organ may trigger protection against ischemia in other organs – this phenomenon is called as the remote ischemic preconditioning (RIPC). We aimed to study the effects of repeated episodes of forearm I&R on one site on different features of arterial pressure waveforms on the contralateral arm in healthy people. 86 healthy volunteers (22+/-1,9 years) were resting in a sitting position. Finger arterial pressure waveform was recorded continuously and non-invasively (Portapres 2, FMS, The Netherlands) during 100-second rest, then 100-second forearm ischemia of the contralateral forearm (caused by inflation of the brachial arm with the pressure 60 mmHg over personal systolic blood pressure), and 100-second reperfusion. The recordings were then repeated twice, each time the ischemia was started 10-minutes after the onset of the preceding reperfusion. With the pulse contour analysis, we measured mean blood pressure (MBP), arterial compliance (Compl), distensibility (Dist), and total peripheral resistance (TPR). Two-way ANOVA was applied for testing the effects of I&R as one factor and preconditioning (3 repetitions of I&R) as another factor. Results are presented as mean +/- standard deviation. There were no significant effects of I&R on the studied features of arterial pressure waveforms (the first factor). However, the repetitions of I&R (i.e., the preconditioning as the second factor) induced significant reductions in MBP (p<0.001) and TPR (p=0.001), and increases in Compl (p=0.007) and Dist (p=0.001). Pairwise comparisons showed that the significant differences were present as early as during the second I&R and further improved after the third I&R. RIPC induces significant vascular changes in healthy individuals. RIPC reduces blood pressure and vascular resistance and improves arterial compliance and distensibility on the contralateral arm.