Previous studies (Alada et al; 2005) have shown that beta adrenergic receptors may be involved in glucose-induced increases in intestinal glucose uptake in dogs. It is however not clear if adrenergic receptors are also involved in intestinal glucose uptake induced by other sugars apart from glucose. The present study therefore investigated the involvement of adrenergic receptors in intestinal glucose uptake caused by infusion of fructose, galactose and glucose during postprandial state. Experiments were carried out on fasted, male, adult mongrel dogs anaesthethized with intravenous injection of sodium pentobarbitone (30.0mg/kg) and divided into four groups with 5 dogs per group. Group I was given i.v infusion of normal saline, group II was given i.v infusion of fructose (1.1mg/kg/min), galactose (1.1mg/kg/min,) or glucose (1.1mg/kg/min), groups III and IV were pretreated with prazosin (0.2mg/kg, i.v) and propranolol (0.5mg/kg, i.v) respectively followed by i.v infusion of fructose, galactose or glucose. Through a midline laparatomy, the upper jejunum was secured and cannulated for blood flow measurement. Blood samples were obtained for measurement of glucose content of arterial and venous blood from the upper jejunal segment.The blood glucose was determined by glucose oxidase method and intestinal glucose uptake was calculated as the product of jejunal blood flow and arterio-venous glucose difference. Values are means ± S.E.M, compared by ANOVA and Student t-test. Propranolol treatment decreased intestinal glucose uptake induced by fructose, galactose and glucose from 240.87±21.2mg/dl/min, 184.15±17.8mg/dl/min, and 314.23 ±16.5mg/dl/min to 150.18± 16.9mg/dl/min, 96.34±10.4 mg/dl/kg and 120.45±23.6 mg/dl/min respectively. Prazosin had no effect on the intestinal glucose uptake induced by fructose and glucose. It however significantly reduced galactose induced increase in intestinal glucose uptake from 184.15±17.8mg/dl/min to 85.17±14.5 mg/dl/min. The results therefore seem to suggest that beta adrenergic receptors are involved in the intestinal glucose uptake caused by administration of fructose, galactose and glucose.