The sympathetic nervous system contributes importantly to the regulation of beat-to-beat arterial blood pressure (ABP) via baroreflex control in humans. Bursts of muscle sympathetic nerve activity (MSNA) occur more frequently during spontaneous reductions of ABP and are typically suppressed during increases in ABP. These transient variations of MSNA appear to correspond most closely with diastolic arterial pressure (DAP) fluctuations. Recent studies demonstrate that the regulation of resting MSNA is sex-dependent, yet relations between MSNA firing patterns and DAP in men and women are not well defined. The purpose of the present work is to determine if DAP-MSNA relations, as well as firing patterns of integrated MSNA, differ in young, otherwise healthy men and women. Our findings reveal that men demonstrate higher DAP-MSNA coherence and an increased percentage of consecutive bursts (i.e., two or more bursts in successive R-waves) compared to women. Moreover, DAP-MSNA coherence is significantly correlated to percentage of consecutive bursts in men, but not women. Because DAP-MSNA relations at rest may not necessarily represent DAP-MSNA relations during orthostasis, we also examined DAP-MSNA coherence and percentage of consecutive bursts during orthostatic stress induced via progressive lower body negative pressure (LBNP). DAP-MSNA coherence is strong (i.e., r≥0.5) and incrementally increases throughout progressive LBNP stages in men. In contrast, DAP-MSNA coherence is significantly lower in women during progressive LBNP, and does not demonstrate similar incremental increases as observed in men. Men demonstrate a higher percentage of consecutive bursts during baseline and all stages of LBNP, although the percentage of consecutive bursts increases similarly during progressive LBNP between sexes. In conclusion, men and women demonstrate different firing patterns of integrated MSNA that appear to be related to differences in DAP oscillatory patterns. Men tend to have more consecutive bursts which contribute to stronger correlations between DAP and MSNA at rest and during orthostatic stress. These findings may help explain why young women are more prone to orthostatic intolerance.