The prevalence of obesity and hypertension among women in Saudi Arabia is increasing at an alarming rate (Al-Nozha et al., 2005). The relationship between obesity and hypertension is well established with obese subjects tending to have higher BP than the non-obese, even in the normotensive range (Kotsis et al., 2010). Most clinical weight loss interventions recommend a five to ten percent weight loss – a level which has been shown to result in a significant drop in blood pressure especially among young women (Andrade et al., 2012). This level of weight loss is however difficult to achieve and maintain (Sarlio-Lahteenkorva et al., 2000). We therefore evaluated the effects of a minor (~2.5%) loss of body weight on systolic blood pressure (SBP), baroreceptor sensitivity (BRS) and sympathetic modulation in young women. Twenty-five women volunteers were randomly assigned to a 4-week dietary weight-loss or weight-maintenance program. Spectral analysis of beat-to-beat blood pressure variability was used to derive sympathetic modulations prior to and after 4 weeks. Baroreceptor sensitivity was determined using regression coefficients between the rise in systolic pressure and the widening of the RR interval following Valsalva’s maneuver. Statistical analyses used were a two- (control vs experimental group) by two (pre and post treatment) analysis of variance (ANOVA) and posthoc analyses. The weight loss group lost ~2.5% of their weight; this resulted in a significant drop of 7.5% in SBP (p < 0.05), a significant increase in BRS (p < 0.05), and a significant decrease in sympathetic modulation at rest (p < 0.05), compared with no significant changes in the weight maintenance group. Our study suggests that minor weight loss may decrease cardiovascular disease risk factors in young women. We propose conducting longitudinal studies involving minor but repeated additive weight losses as a non-pharmacological intervention for obesity.