Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is carried out by a subpopulation of GABAergic interneurons that display dense and widespread axonal arborisations (Bonifazi et al. Science 2009). However the fate of hub neurons remains unknown. Specifically it is unclear whether these hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the complexity of the GABAergic neurons and the poor expression of interneuron markers at early developmental stages. To circumvent this conundrum we used “genetic fate mapping” that allows for the selective labelling of interneurons based on their place and time of origin. Following theoretical predictions, we tested the hypothesis that pioneer cells could develop into hub neurons.