The aim of the study was to investigate the alteration of different EEG characteristics in epileptic children during the treatment with Antiepileptic Drugs (AEP) – Depakin. 46 patients aged 3 to 9 (28-boys, 18-girls) were examined. Generalised seizures were observed in 25 and partial seizures in 21patients. All the patients underwent of the qEEG recording at the first visit prior to the administration of any anticonvulsants, further 3-4 and 6-8 months after the start of D consumption. The following EEG characteristic were analyzed: – the EEG pattern with monopolar, bipolar and common average references montage for the evaluation of the background activity and presence of epileptiform element; Absolute values of the power spectra (AVP) of activity delta theta, alpha, beta waves were analyzed; Spatial distribution topography of the selected ranges of activity over the brain convexital surface. D appears significantly reduce the total AVP indices practically in all zones recorded from the brain’s well expressed decrease was observed in temporal and occipital areas. During the treatment course showed a significant decrease in AVP of low-frequency range in temporal, parietal and occipital areas. It must be stressed out the most prominent decrease of AVP within the range of beta. The EEG analysis of D to influence on epileptiform graphoelements shows primarily in the reduction of epileptiform complexes spike-wave and sharp waves. Complete reduction of this elements in the resting EEG was observed practically as early as 3 months after the beginning of the treatment. At the same time, the influence of D sharp waves, as well as on paroxysmal bursts provoked by functional tests was expressed to a less extent: these graphoelements continued to be recorded after 6-8 months after the commencement of the treatment.