Backgrounds: The Ou MC decrescendo phenomenon (OuDP) involves the placing of the contralateral hand of the examiner on the acute abdomen of female patients, which results in an alleviation of pain (Ou MC manipulation) [1,2]. Such phenomenon is associated the interaction of bilateral parts of topographically symmetrical living beings.Methods: Two front-end observations (2006-2011) showed that placement of the contralateral hand on the acute abdomen of women alleviated pain (78 of 81 women or 96.3%), while placement of the ipsilateral hand did not (0 of 39 women or 0%) [1,3]. This method named as Ou MC handing remedy (HR) ( Fig. 1) was used to observe the immediate and cumulative effects of OuDP on 38 cases, of which 27 were self-administered and 11 were administered by the therapist [2,3]. The severity of pain was evaluated with a visual analog scale by the patients. Symptoms or signs beyond pain were documented with serial clinical evaluations and the Unified Parkinson’s Disease Rating Scale for a case with Parkinsonism [3]. All patients agreed for participation with an informed consent.Results: Five minutes after initial self-administered HR, there was pain alleviation in 14 cases and improved symptoms or signs beyond pain for another 6 cases while 7 cases unevaluated. Final results showed 9 cured, 5 with partial remission and the remaining 13 with complete remission. Five minutes after initial therapist-administered HR, pain alleviation was found with 10 cases while 1 case unevaluated. The final results showed 7 cases cured, 2 with partial remission, and 2 with complete remission. (Table 1) The pain with the infection of 8 cases relieved with the resolution of infection. The joint pain of 12 patients immediately alleviated with HR and remitted finally. Immediate decrease of uterine bleeding of a case with uterine leiomyosarcoma and cure of the perineal macular lesion of a case with chronic myelogenous leukemia were observed. Two cases changed from therapist to self-administerd treatment to increase frequency and duration of HR. The effects of OuDP are related to the duration, frequency of administration and the distance between the hand and the lesion. [3] Conclusions: The resolution of non-infectious conditions (23/38) with OuDP is consistent with the restoration of normal tissue function, which seems to contribute to pain alleviation and defense against infections and tumors. Studies show that the contralateral snapper claw of the snapping shrimp affects the development of the new claw in both shape and fiber composition to achieve a bilateral symmetry and the exposure to conspecific mutual interactions of other snapping shrimps also triggers such claw transformation [4]. Similarly, OuDP is induced by the interaction of human bilateal parts (hand to body) and also can be invoked via HR using either self or therapist administration [2,3]. What signals are imparted during such exposure to such interaction remains to be elucidated.