The present study investigated the role of BLA adrenergic receptors (ARs) in hippocampus dependent spatial memory processes in place avoidance task in male rats. Long Evans rats (n=150) were trained to avoid footshock in a 60 degree segment while foraging for scattered food on a circular (80-cm diameter) arena. The rats were injected bilaterally in the BLA with the specific ARs agonist [(Norepinephrine (NE) (0.5 and 1 microgram per microliter] and specific ARs antagonist [(Propranolol (PRO) (0.5 and 1 microgram per microliter)] before acquisition, after training or before retrieval of the place avoidance task. Control rats received vehicle the same volume. The learning in a single 30-min session was assessed 24h later by a 30-min extinction trial in which the time to first entrance and the number of entrances to the shocked area measured the avoidance memory. Acquisition and consolidation were enhance (dose dependently) and impaired when the drug was injected 10 min before training, immediately after training respectively in both doses (P0.05). These findings indicate that adrenergic drug affect on memory storage at least in part by binding directly to ARs in the BLA and provide further evidence for the opinion that the BLA plays an important role in integrating hormonal and neurotransmitter influences on memory storage.