Hypertension is a medical condition that does not have specific clinical manifestations until organ damage sets in and its prevalence is said to be highest in Africa1. Hence, the need for a study to assess and compare vascular reactivity in normotensive male and females Nigerians in order to screen for those at risk of developing hypertension. Thirty-six apparently healthy, normotensive male and female Nigerians, aged 18years – 37years were exposed to cold pressor test (CPT) after informed consent was obtained from the subjects and approval had been granted by the Grants and Experimentation Ethics Committee of the College of Medicine of the University of Lagos. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured before and after exposure to the CPT. Blood pressure was determined by auscultatory method. Subjects were instructed to immerse one foot up to the ankle into ice slurry maintained at 4°C for 1 minute2. Vascular hyperreactivity was determined as an increase in the subject’s systolic or diastolic blood pressure ≥15 mmHg after exposure to the CPT3. Subjects whose blood pressure showed a rise < 15 mmHg be it systolic or diastolic, were designated normoreactive. Data are expressed in mean ± SEM, using GraphPad Statistical Software, Version 5 for Windows (GraphPad Software, San Diego, California, USA). Changes in SBP and DBP in the subjects were analyzed using Student’s t- test and p < 0.05 was considered significant. In the parameters measured, SBP and DBP increased significantly (p< 0.05) after exposure to CPT. There was no significant difference (p> 0.05) in SBP and DBP responses to the CPT between the male and female subjects. Systolic hyperreactivity was observed in 56% of the male subjects while 50% of them demonstrated diastolic hypereactivity. On the other hand, 50% of the female subjects showed systolic hyperreactivity while 56% of them demonstrated diastolic hyperreactivity, indicating vulnerability of these individuals to the development of hypertension in the future.4 Since at least, half (50%) of the population studied, were hyperreactive in their SBP or DBP, drastic action on preventive measures should be targeted at those at risk of developing hypertension so as to step-down the rising incidence and prevalence of hypertension in Africa.