Water infusion of Hunteria umbellata (K. Schum) Hallier f. seed is highly valued in African folk medicine for the local management of diabetes, hyperlipidemia and obesity. Earlier studies have reported the antihyperglycemic, anti-obesity and antihyperlipidemic activities of the aqueous seed extract of this plant in different experimental models. The present study, however, investigates the weight losing and antihyperlipidemic potentials of 25 and 50 mg/kg of the crude alkaloid fraction (HUAf) in normal and triton-induced hyperlipidemic rats, Hunteria umbellata seed being known to be a rich source of alkaloids. In addition, the possible weight losing and antihyperlipidemic activities of this alkaloid fraction were investigated. Adult male Wistar rats (weight range: 120-150 g) were randomly divided into 4 and 5 treatment groups in the normal and triton-induced hyperlipidemic models, respectively, and were treated for 14 days before they were humanely sacrificed under inhaled diethyl ether anesthesia. Five (5) ml of whole blood was obtained by cardiac puncture from each treated rat from which serum for lipids assay was subsequently separated from. Results showed that repeated daily oral treatments of normal rats with 25 and 50 mg/kg of HUAf dissolved in distilled water in dissolved in 10% Tween 20 (9:1) for 14 days resulted in significant (p<0.05 and p<0.001) and dose-dependent weight loss, decreases in the serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) while significantly (p<0.001) increased the serum levels of high density lipoprotein-cholesterol (HDL-c) fraction. Similarly, oral pretreatments with 25 and 50 mg/kg of HUAf for 14 days before hyperlipidemia induction with intraperitoneal injection with triton WR 1339 significantly (p<0.01, p<0.001) and dose-dependently attenuated increases in the average body weights, serum levels of TG, TC, LDL-c while also significantly (p<0.01, p<0.001) and dose dependently attenuated significant (p<0.001) decrease in the serum HDL-c levels when compared to the untreated control values. However, the results obtained for 50 mg/kg of HUAf in both normal and triton WR 3339-induced hyperlipidemic rats were comparable to that recorded for 20 mg/kg of simvastatin. In conclusion, the results of this study show that repeated oral treatments with 25 and 50 mg/kg/day of HUAf have weight losing and antihyperlipidemic effects which were mediated via enhanced lipids biliary excretion.