Studies carried out across organisms and model systems collectively show that adaptive homeostasis declines with advancing age. Exercise is a well-studied physiological stress that is capable of extending healthspan. Current understanding of the beneficial adaptations to exercise that occur across virtually every physiological system is considerable and continually growing. However, much less is understood about how important these adaptations are for resistance or resilience in face of increasing stresses brought about by aging. Therefore, defining the current understanding and identifying knowledge gaps about exercise as a means to prevent a loss in adaptive homeostasis with age is critical for directing future research efforts.
This symposium brings together leaders in the fields to address exercise and adaptive homeostasis in the context of ageing across tissues at a number of biological levels using a variety of model systems.