H3 Symposium: Microvascular physiology-implications for understanding intravenous fluid therapy

28 November 2014

Hodgkin Huxley House,
30 Farringdon Lane,
London EC1R 3AW, United Kingdom

Organised by Geraldine Clough and Tom Woodcock (University of Southampton, UK)

This event is now full, but you can watch the livestream on Friday 28 November from 10.00

This is a joint meeting with the Association of Anaesthetists of Great Britain and Ireland (AAGBI)


Physiologists Ernest Starling and William Bayliss served on the first Medical Research Committee during the Great War of 1914-18 to find a treatment for wound shock.

They invented the idea of intravenous biophysical colloid therapy.  The use of colloids has been justified by the belief that an infused colloid solution should preferentially resuscitate the intravascular fraction of the extracellular fluid volume. Mechanisms for this were thought to be through an enhanced oncotic gradient across the capillary wall favoring reabsorption of fluid from the extravascular space and/or through the interaction of the infuse colloid with the endothelial cell surface glycocalyx.

In recent years the beneficial effects of infused colloids has been challenged and semisynthetic colloids reported to have an adverse safety profile. Thus the advantages and limitations of colloids for fluid resuscitation and the mechanisms by which they may have their advantageous or disadvantageous effects remain unresolved. Moreover, the failure of undergraduate textbooks and physiology teaching to adequately cover this important topic and poor knowledge of fluid prescribing among the primary prescribers (foundation doctors) suggests that it is timely to review the topic.

This one day symposium brings together researchers, clinicians, teachers and opinion holders to address omissions in vital knowledge in the field and produce an improved paradigm for the use of intravenous fluid therapy.

Confirmed Speakers

  • Kenton Arkill (University of Birmingham, UK)
  • Gordon Drummond (University of Edinburgh, UK)
  • Christiane Hartog (Jena University Hospital, Germany)
  • Matthias Jacob (University of Munich, Germany)
  • Charles Michel (Imperial College London, UK)
  • Michael Mythen (University College London, UK)
  • Tom Woodcock (University Hospitals Southampton NHS Trust, UK)

Key features

  • Poster competition, supported by AAGBI, for those at an early stage in their career (undergraduates, PhD students & clinical trainees).  We welcome abstracts from all Society Members, and also AAGBI members.
  • 'Meet the speakers' networking and drinks reception supported by AAGBI.

Spaces are limited so register early.  

Please note this symposium will be filmed and live streamed by The Physiological Society. If you have any objections please contact events@physoc.org