Cigarette smoke directly damages muscles in the body

24 May 2018. Not only is smoking bad for your lungs, but new research shows that components in cigarette smoke directly damage your muscles. The research, published in The Journal of Physiology, indicates that smoking decreases the number of small blood vessels that bring oxygen and nutrients to muscles in the legs.

We know that smoking limits a person’s ability to exercise because it makes their muscles weaker. It was widely believed this muscle weakness is because the lungs become inflamed and eventually destroyed by habitual smoking, therefore limiting activity and exercise. 

However, the findings of this study suggest that cigarette smoke directly damages muscles by reducing the number of blood vessels in leg muscles, thereby reducing the amount of oxygen and nutrients they can receive. This can impact metabolism and activity levels, both of which are risk factors for many chronic diseases including chronic obstructive pulmonary disease (COPD) and diabetes.  

The research conducted by the University of California, San Diego in conjunction with Universidade Federal do Rio de Janeiro and Kochi University, involved exposing mice to smoke from tobacco cigarettes for 8 weeks, either by inhalation or by injecting mice with a solution bubbled with smoke. 

The study did not identify which of the approximately 4,000 chemicals in cigarette smoke are responsible for this muscle damage. Identification of the responsible chemicals is a key avenue of further research, along with understanding the process by which they reduce the number of blood vessels. 

Ellen Breen, the lead investigator commented on the study:

‘It is vitally important that we show people that the use of tobacco cigarettes has harmful consequences throughout the body, including large muscle groups needed for daily living, and develop strategies to stop the damage triggered by the detrimental components of cigarette smoke.’  

ENDS

Notes for Editors

1. Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofiber calcium kinetics in C57BL/6J mice https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP275888

2. The Journal of Physiology publishes advances in physiology which increase our understanding of how our bodies function in health and disease. http://jp.physoc.org 

3. The Physiological Society brings together over 3,500 scientists from over 60 countries. The Society promotes physiology with the public and parliament alike. It supports physiologists by organising world-class conferences and offering grants for research and also publishes the latest developments in the field in its three leading scientific journals, The Journal of Physiology, Experimental Physiology and Physiological Reports. www.physoc.org 

4. The figure below indicates cigarette smoke components whether delivered by inhalation or more directly into the circulation negatively impact the fatigue resistance of skeletal muscle. Credit: Dr Leonardo Nogueira. 

Impact of cigarette smoke on muscles

Contacts

The Physiological Society:
Andrew Mackenzie, Head of Policy and Communications
pressoffice@physoc.org 
+44 (0)20 7269 5728 

Corresponding author:
Ellen C. Breen
Department of Medicine, University of California San Diego
ebreen@ucsd.edu