Overweight and obesity have a huge impact on skin pathophysiology. Various related skin disorders seem to involve significant changes in skin hydration and biomechanical characteristics. However related biomarkers are difficult to obtain and to understand, considering skin’s intraindividual’s variability . This study aims to identify functional biomarkers to describe related changes in skin physiology. The study involved 89 female volunteers, between 19 and 46 (32±7) years old, without any pathologies besides overweight and obesity. All procedures observed the Declaration of Helsinki and subsequent ethical guidelines. Individuals were characterized according with their BMI following the WHO definitions, and cutaneous variables. These, obtained by noninvasive methods, under standard and controlled conditions included skin’s epidermal hydration (corneometry), barrier function (TEWL) and several biomechanical descriptors. Z-scores were obtained to designed overall descriptors for hydration and biomechanics respectively. Since some of the indicators were distributed in a reverse scale (the higher the absolute value, the worse the performance of skin) the z-score of these variables became their symmetrical. The global indicators (for each anatomic region) were calculated using the arithmetic mean between these altered partial indicators. Statistical analysis was performed using SPSS version 20.0 and a significance level of 95% adopted. Data revealed a direct relationship between hydration and biomechanical markers in different anatomical regions. Paradoxally, this is reversed with morbid obesity where an inverse association between skin hydration and biomechanical markers is consistently detected. In any case these relations follow the tendency of isolated descriptors. No matter the tendency, no significant correlation was found in the breast area. This strategy proved to be useful to design global indicators of these functional variables by anatomical area, allowing a fast and clearer view on skin’s functional condition.