Aging is the major risk factor for developing cardiovascular complications like endothelial dysfunction, aneurysm formation, acute myocardial infarction and heart failure. The mechanisms involved in cardiovascular aging are poorly understood, but microRNAs (miRNAs) have emerged as key biological regulators. We have identified that age-induced miR-29 has a causal role in aneurysm formation by regulating the expression of extracellular matrix proteins in the aorta. Furthermore, we recently described the crucial role for miR-34a in cardiac aging, which regulates cardiomyocyte apoptosis and telomere length by targeting the protein phosphatase nuclear targeting subunit PNUTS. Current studies in the laboratory focus on determining the role of miRNAs, their targets and their transcriptional regulators in aging of the endothelium and how these affect organ homeostasis and cellular metabolism.