Objective: The purpose of this study was to identify physical activity profile in Moroccan patients with rheumatoid arthritis (RA) and to search factors related to physical inactivity in those patients suffering from this chronic rheumatic disease. Methods: A cross sectional study was conducted in 103 RA. Socio-demographic characteristics and Disease specific variables were documented .Disease activity was measured with Disease Activity Score 28 (DAS28), quality of life was assessed with rheumatoid arthritis impact disease (RAID), fatigue was evaluated by fatigue Visual Analogic scale and Health Assessment Questionnaire (HAQ) was completed by all patients. Physical activity was evaluated with the Arab version of the International Physical Activity Questionnaire (IPAQ) short version.Results: A total of 90 women and 13 men with RA participated in this study. Mean age of participants was 49.7±11.4 years. The median disease duration was of 8.2 years [3.2-14.2]. Total amount of physical activity was a median of 1873 (346-4053) MET-minute/week. The physical activity was low in 30.8% of participants. In univariate analysis lower physical activity (IPAQ) correlated with higher disease activity (OR=-3.9 ; CI95%-899–300 ;p<0.001) ; poor functional capacity (OR=-4.5 ; CI95%-2146–845 ;p=0.001); higher fatigue levels (OR=-2.3 ; CI95%-43.4—3.3 ;p=0.02) and low quality of life (RAID) (OR=-2.8; CI95%-610–107p=0,006). No relationship was found between Physical activity and age, disease duration nor with BMI. After multivariate analysis, HAQ (OR=-3.1; CI95%-991—85;p=0.002) and DAS28 (OR=-3.1;CI95%-2587—606) were the independent factors associated with low physical activity. Conclusion: This study suggested that lower physical activity associated with high disease activity and poor functional capacity. Future larger studies are needed to confirm our results.