Cancer is characterized by persistent proliferation and regeneration of cells. Breast cancer involves breast tissue cells and is a top most cause of deaths in women. Breast cancer resistance protein is the key player in breast carcinoma. Current study was designed to observe the expression level of breast cancer resistance protein encoded by ABCG2 gene which plays a pivotal role in contribution of resistance to multidrug therapy in cancer patients as well as pharmacokinetics of xenobiotic and other anticancerus drug therapies. Gene expression analysis was determined by using Qualitative real-time PCR. FOXO and micro-RNA play a key role in regulation of ABCG2 breast cancer resistance gene and it is determined by gene expression analysis. ABCG2 protein is down-regulated by significantly higher expression level of MIR 140, MIR 145 and MIR 328 in breast cancer patients. In breast cancer patients’ mTOR and Src genes are highly expressed. Data was analyzed statictically by applying ANOVA and for significance of data DMR was used. Results concluded that the down regulation of ABCG2 gene will lead to failure of chemotherapy and mutidrug resistance in breast cancer patients.
Future Physiology (Leeds, UK) (2017) Proc Physiol Soc 39, PC27
Poster Communications: microRNAs down regulate the breast cancer resistance protein (ABCG2 gene) in female breast cancer
S. Saeed1, M. Faisal1, W. Majeed1, F. Muhammad1, J. HUSSAIN1, H. Muzaffar1, A. Mahmood1, A. Abdul Sadiq2
1. Institute of Pharmacy,Physiology and Pharmacology,Faculty of Veterinary Science, University of Agricultre, Faisalabad, Faisalabad, Pakistan. 2. Department of Zoology, Aswan University,Egypt, Aswan, Egypt.
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Where applicable, experiments conform with Society ethical requirements.