Graham Baker graduated in physiology in 1969, gained a PhD and was appointed lecturer at Bedford College in 1981. Throughout his career he worked predominantly on transport systems, most notably in human erythrocytes (with Wilfred Widdas) using self-built equipment. He discovered the asymmetric action of 4,6 O-ethylidene-D-glucose in inhibiting glucose transport, investigated the effect of ATP on phloretin activity (with Martha Kaloyianni) and hypothesized, with Richard Naftalin, a structural explanation for the apparent variable affinity of the glucose transporter. He was also interested in transport across the nasal mucosa, evolving a number of techniques to study the human airways in vitro, with implications for the understanding of air pollution and asthma.

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