Changes in skin physiology resulting from overweight appears to be associated to significant modifications in skin hydration, repair mechanisms and biomechanical behavior, but this subject is still poorly documented. The aim of this work is to evaluate the impact of the BMI on normal skin indicators. Our sample involved 89 female volunteers, 20 – 46 (32+7) years old, no relevant pathologies except overweight, obesity and morbid obesity. The study respected the Declaration of Helsinki and subsequent ethical guidelines. Volunteer’s weight and height were obtained by anthropometric measurements and the BMI calculated. The sample was divided in four groups according to the WHO classification – Normal (group I), Overweight (group II), Obese(group III) and Morbid (group IV). One single measurement (noninvasive methods, under standard and controlled conditions) was performed, involving measurements on skin hydration, barrier function and biomechanical behavior, in three different anatomical sites: face (zygomatic and forehead), breast and abdomen. Descriptive and comparative statistics were applied (SPSS vs 20.0) and a 95%.significance level adopted. TEWL, Hydration and mechanical descriptors follow a U-shape or a J-shape relationship regarding the BMI as described for other risk biomarkers for cardiovascular disease. An increase in TEWL and a decrease on skin hydration is noted in all anatomic areas when normal subjects are compared with morbid obese. Regarding biomechanical descriptors, significant reductions are detected in all anatomic areas, especially in abdomen, specially involving morbid obesity. Overweight definitely affects skin’s function and appearance. These hydration and biomechanical descriptors seems to be interesting biomarkers of the process and eventually correlate with the signs and symptoms that characterize these patient’s (most frequent) complaints.