Obesity is an important risk factor of arterial hypertension. The impairment of baroreflex – a principal blood pressure control mechanism – could contribute to the development of hypertension in obese patients. Previous studies found a decreased baroreflex sensitivity (BRS) measured by transfer function analysis of spontaneous blood pressure (BP) and heart rate (HR) oscillations in obese subjects. However, this method ignores the causality and directionality of HR and BP oscillations interactions. The novel method for separate analysis of feedback (baroreflex) and feedforward (mechanical) interactions between HR and BP was recently developed. The aim of the study was to analyse BRS in obese normotensive children and adolescents using causal baroreflex analysis method. Continuous recordings of BP (volume-clamp method) and R-R intervals (ECG) were obtained from 40 obese subjects (aged 10-18 years) and 40 age and gender matched controls. Causal close loop model was used to measure classical (noncausal) BRS and causal feedback interaction from BP to HR (causal BRS). The noncausal BRS did not show any significant difference between groups. On the other hand, causal BRS was significantly lower in obese group. In conclusion, the causal BRS analysis is more sensitive in early detection of baroreflex impairment in obese children and adolescents compared to classical BRS method. The results points towards baroreflex as one of the mechanisms involved in future hypertension development in obese patients.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, PCC037
Poster Communications: Causal baroreflex sensitivity analysis from spontaneous heart rate and blood pressure oscillations in obese children and adolescents
M. Javorka1, I. Tonhajzerova1, B. Czippelova1, Z. Turianikova1, L. Chladekova1, K. Javorka1
1. Department of Physiology, Comenius University, Jessenius Faculty of Medicine, Martin, Slovakia.
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