Pacemaker HCN channels contribute to pacing in the mammalian sinoatrial node (SAN) (1), a region of the heart that determines natural beating rate, as well as in other species such as frog (2) and even the most basal chordates (3,4). Pacemaker channels are unusual in that they are opened by hyperpolarization and bind cAMP, which facilitates opening. Here, I discuss recent findings on how this channel is unusually modified by cyclic nucleotides and voltage.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, SA384
Research Symposium: Control of pacemaker HCN channel function by cAMP and voltage
E. Accili1
1. University of British Columbia, Vancouver, British Columbia, Canada.
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Where applicable, experiments conform with Society ethical requirements.