In current poultry production systems use of antibiotic is going be inevitable for efficient meat production and among the antimicrobial agents quinolones are proved to be efficient in curing various bacterial diseases of poultry. However, the residual effects of norfloxacin (one of the quinolones) in meat of broiler birds have not been largely addressed. Therefore, we aimed to investigate the effect of norfloxacin residues on the quality of broiler meat by measuring the oxidant status and antioxidant capacity. Five weeks old broiler birds were experimentally administered with norfloxacin (10 mg/kg b.wt/day) for 5 consecutive days through drinking water. Six birds were killed for each time interval to detect the norfloxacin residues by HPLC with fluorescent detection as well as oxidant and antioxidant capacity of serum and muscles was measured by photometric method. Animal experimentation was conducted according to the institutional ethics committee. Maximum drug residues were present in serum and muscles on day 1 of norfloxacin treatment. Norfloxacin did decrease the antioxidant capacity in serum and muscles of medicated chicken that may lead to deterioration of broiler meat The reactive oxygen species (ROS) production (oxidative capacity) increased in serum and muscles at day 1 of norfloxacin treatment in broiler birds. However, after 4 days of wash out period for drug, the antioxidants status was improved without any significance.. In conclusion our results did show that residues of norfloxacin have deteriorative effects on meat quality of chicken.