Disrupted in Schizophrenia 1 (DISC1) is an increasingly well-validated schizophrenia risk gene, which is associated with cognitive deficits in both schizophrenics and the normal ageing population. In our original studies we generated a network of protein-protein interactions (PPIs) around DISC1, achieved by utilizing iterative yeast-two hybrid screens, combined with detailed pathway and functional analysis. This so-called ‘DISC1 interactome’ contains many novel PPIs and provides a molecular framework to explore the function of DISC1. We have characterized two of the DISC1 partnerships, with PDE4 and Ndel1, in detail in great examples of Industry-Academia collaboration. It is clear from our studies that DISC1 is able to interact with a wide range of proteins and has the profile of a key ‘hub’ protein within these networks. Our own studies and those of others will be discussed in the context of the overall interactome and implications for new therapies for this disease.