Skeletal muscle mitochondria are highly adaptable and respond to exercise training by multiple mechanisms. In humans, exercise modulates the different electron transport chain complexes distinctively. Among the molecular adaptations, exercise favors the shift of free complexes into functional supercomplexes assemblies. These observations suggest that free and superassembled complexes co-exist and are recruited in response to energy demand. The content of supercomplexes is positively related to muscle respiration and exercise efficiency.
Europhysiology 2018 (London, UK) (2018) Proc Physiol Soc 41, SA045
Research Symposium: Effects of exercise on mitochondria respiratory supercomplex assemblies
F. Amati1
1. Department of Physiology and Institute of Sports Sciences, University of Lausanne, Lausanne, Switzerland.
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Where applicable, experiments conform with Society ethical requirements.