The study evaluated the effect of nickel (Ni) and stress on anxiety and depression in wistar rats. Forty rats, divided into control and three test groups (n = 10), were injected intraperitoneally with normal saline (0.9% NaCl) or nickel (II) chloride (NiCl2) solution – 25 mg/kg dosage – and some were stressed using restraint model for 2 weeks. After the treatment period, animals were tested using forced swim test and tail suspension for depressive-like behavior and in the elevated plus maze for anxiety-like behavior. The brain of each animal was taken for biochemical examination. The results showed that Ni administration and stress significantly increased depressive-like behavior. A significant increase in anxiety-like symptoms was also exhibited by Ni treated and stressed rats. With regard to biochemical analysis, activity of catalase (CAT) and myeloperoxidase enzyme were significantly decreased. Consequently, Ni administration and stress exposure induced depression, anxiety and biochemical dysfunctions.
Future Physiology 2020 (Virutal) (2020) Proc Physiol Soc 46, PC0138
Poster Communications: EVALUATION OF THE EFFECT OF NICKEL AND STRESS ON ANXIETY AND DEPRESSION IN WISTAR RATS
Progress Ajayi1, Oritoke Aluko1
1 Department of Physiology, School, of Health and Health Technology, Federal University of Technology, Akure, Nigeria
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Where applicable, experiments conform with Society ethical requirements.