Globally, diabetes mellitus is increasingly becoming public health concern that care and prevention would be of paramount importance. Avocado peel has been exploited as folk remedies linked to all kinds of health problems including diabetes. This work was carried out to evaluate the therapeutic efficacy of hydroethanolic extract of avocado peel as hypoglycaemic, antihyperglycaemic and anti-lipid peroxidation. Six groups of 10 healthy male wistar rats were used for the study. Control Group1 were given drinking water; Group 2 glibenclamide (0.6mg/kg/day); Group 3 Avocado peel extract (50mg/kg-1); Group 4 streptozotocin (60 mg/kg-1) diabetic; Group 5 diabetic + glibenclamide; Group 6 diabetic + avocado peel extract. Both blood glucose and glycated haemoglobin levels were assayed at age 0, 21, and 42 days respectively. Pancreas was analyzed for lipid peroxidation production of malondialdehyde (MDA) and isoprostanes (F2isoP). Like glibenclamide, avocado peel extract time-dependently significantly (<0.05) lowered blood glucose and glycated haemoglobin, as well as significantly down-regulated MDA and F2isoP in comparison to non-diabetic and diabetic control respectively. Correlation analysis revealed possible link between oxidative stress and impairment of glucose regulation. In conclusion, avocado peel extract can ameliorate blood glucose regulation possibly through its antioxidant mechanisms. So, we can recommend that avocado peel extract should be considered in the management plan of diabetics.