This study investigated the effects of oral administration of alcohol and cannabinol on reproductive system in male adult rats. Twenty five male rats were divided into five groups containing five rats each and were treated for a period of 48 days. Group one serves as the control, group two was administered 5mg/kg body weight methanol, group three was gavaged with 3g/kg body weight as 25%v/v alcohol, group four was gavaged with 10mg/kg body weight cannabinol and group five was treated with alcohol (3g/kg body weight as 20%v/v) and cannabinol (10mg/kg body weight). At the end of the experimental period, blood was collected via the retro-orbital sinus and was allowed to clot for hormonal assay. The animals were sacrificed and their reproductive organs were removed and weighed immediately. There was no significant change in the body weight but there was a significant change in the percentage weight difference in the experimental groups when compared with the control group. Serum level of testosterone of the groups treated with alcohol, cannabinol, alcohol plus cannabinol were significantly decreased when compared with the control rats. However, there were reduction in sperm motility and sperm count of rats exposed to alcohol, cannabinol, alcohol plus cannabinol treated rats in comparison to the control rats. The histological section showed alteration in the testicular cytoarchitecture in groups treated with alcohol or/and cannabinol treated rats.. The results suggest that alcohol and cannabinol administration have deleterious effect on male reproductive activities (system) in rats by altering the parameters tested for..Key words: Alcohol, cannabinol, sperm content, hormone profile, Lipid Peroxidation, Male rat.