Ageing is associated with an insidious loss of muscle mass, impairing functional and metabolic capacity, and negatively impacting both an individual’s lifespan and healthspan. Effectively intervening in this process is a pressing societal and research concern, especially given that the population of older adults is increasing globally. Mechanistically, ageing is associated with a blunted muscle protein synthetic response to protein ingestion. As such, nutritional interventions to combat the anabolic resistance to protein feeding form the bulwark of strategies to mitigate age-related muscle loss. This presentation will review the contemporary evidence base for these protein-centric nutritional interventions, with a particular focus on the source of dietary protein. Additionally, we will explore interactions with exercise and potential novel nutritional interventions.