Since launch of the service at ukpmc.ac.uk in January 2007, scientists working in many areas of biomedical and health research have submitted hundreds of manuscripts UK PubMed Central. This talk provides an introduction to UK PubMed Central. In addition to providing free access to the PubMed Central collection of life science literature, UK PubMed Central currently offers a manuscript submission system at ukpmc.ac.uk/ukmss that enables scientists to make their scientific publications freely available in a new national online repository. UK PubMed Central is run by the British Library and will be developed together with the University of Manchester and the European Bioinformatics Institute to offer further UK-specific services and enhanced content such as links into molecular and medical datasets. The development of UKPMC is supported by principal sponsors of biomedical and health research in the UK.