TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and multi-locular expression. They have been found involved in pain and inflammation. Studies have focused on the role of TRPV4 in peripheral sensory neurons, but its expression and function in central nervous glial cells and neurons has also been documented. In this overview, we will review evidence of TRPV4 function in these two cell types in the CNS, and how TRPV4 function can be modulated for therapeutic benefit of neuro-psychiatric disease. Novel TRPV4-inhibitory compounds developed recently in the author’s lab will also be introduced.
Physiology 2016 (Dublin, Ireland) (2016) Proc Physiol Soc 37, SA011
Research Symposium: Pleiotropic function of TRPV4 ion channels in the CNS
W. B. Liedtke1,2
1. Neurology, Duke University, Durham, North Carolina, United States. 2. Anesthesiology, Duke University, Durham, North Carolina, United States.
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Where applicable, experiments conform with Society ethical requirements.