Heavy metals are ranked among the top 10 of the most 275 most hazardous substances in the environment on the current Priority List of Hazardous substances for the Agency for Toxic Substances and Disease Registry (ATSDR). Of all toxic heavy metals, cadmium ranks the highest in terms of damage to human health. Although, there are many studies which have established the toxic effects of cadmium on biological systems, the mechanism of cadmium detoxification and novel detoxifying agents are still under considerable debate and discussion. Accordingly, the present study aimed at investigating the role of a probiotic bacterial strain and cumin essential oil on the hepatotoxic effects induced by cadmium in experimental rats. Seventy male albino rats were used and were handled in accordance with the principles of laboratory animal care as contained in NIH guide for laboratory animal welfare. The rats were assigned into 7 groups of 10 rats each and were orally administered with cadmium chloride (5 mg/Kg BW), cumin essential oil (0.125 mg/Kg BW) and live culture of Lactobacillus bulgaricus (ca 107 cfu) singly or jointly for a period of 30 days. Following the exposure period blood and liver were collected for biochemical and histological analyses. The in vivo exposure of rats to cadmium induced an array of hepatotoxic effects at both the biochemical and histological levels, which ranged from biochemical irregularities in total protein, albumin, globulin and bilirubin levels to structural changes as manifested by elevations in hepatocellular injury biomarkers (aminotransferases, LDH and AlP) and hepatohistological alterations indicative of necrotic and inflammatory lesions. Moreover, an oxidative stress status was evidenced in liver tissue of rats as inferred by escalation in lipid peroxidation and depletion in antioxidant defense parameters including both non-enzymatic and enzymatic antioxidants (GSH content, GST, CAT and SOD). Cumin essential oil and the probiotic bacterial strain alleviated the hepatic dysfunction associating cadmium toxicity as inferred by the restorative effect on hypoproteinemia, hypoglobulinemia, hypoalbuminemia and hyperbilirubinemia. Structurally they restored hepatocellular injury biomarkers to normal or near normal levels and restored their activities both at the tissue and serum levels. Moreover, they preserved the hepatic histological architecture where the hepatic lesions associating cadmium toxicity were alleviated by their single or joint administration. They also combated the oxidative stress status induced by cadmium in liver tissue. Conclusively, both cumin and Lactobacillus exhibited beneficial effects against the physiological threats posed by cadmium and they hold health promoting effects at the biochemical and histological levels.