Cytokeratin-1 was isolated as a partner of Src tyrosine kinase from neuroblastoma NMB7 cells. The identity of cytokeratin-1 was further confirmed with mass spectrophotometry. This molecular complex of cytokeratin-1/Src was found as an associate with molecular scaffolder RACK1 (Receptor for Activated Protein Kinase C). Of interests, the cytokerain-1/Src/RACK1 was found to be actively reactive with membrane receptors, such as integrin beta 1. We are interested to apply them to trap signal kinase and phosphatase upon cytokine stimulation, especially during neurogenesis.
Life Sciences 2007 (2007) Proc Life Sciences, C83
Research Symposium: Reaction of integrin beta1 with cytokeratin-1 in neuroblastoma NMB7 cells
N. Chuang1, C. Huang1
1. Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan. 2. Dept of Zoology, National Taiwan University, Taipei, Taiwan.
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Where applicable, experiments conform with Society ethical requirements.