Exposure to petrol has been associated with reduced immunity in previous work. This work is aimed at assessing the role played by IL-6 and TNF α in the suspected inflammatory reaction produced by exposure to petroleum product. Methodology: 25 adult male rats were grouped to 5 with 5 rats in each group. All rats were made to inhale petrol for 5 minutes every day for 2 weeks using compressor nebulizer except the control group. Group 1 (control) had normal feed and water ad-libitum. Groups 2,3 and 4 were given moringa oleifera in their feed (ratio 1:4), candesartan (ATI receptor blocker) pre-treatment, captopril ( Angiotensin converting enzyme inhibitor) pre-treatment before inhaling petrol while group 4 had petrol only every day. At the end of the exposure, rats were anaesthesized with chloroform and blood collected into EDTA bottles from the heart. Rat ELISA kit IL6 and TNF α were used by analyzing in duplicate wells for each sample. Result: Significantly increased release of pro-inflammatory cytokins IL6 was observed in the group exposed to petrol only compared with the value in the group pretreated with captopril and moringa oleifera. There was increase in the value of IL-6 in the group exposed to petrol only (89.47±46) compared with the pretreated with captopril (42.05±24) while the group given alovera had the least value(14.88±22). Significantly increased serum level of TNF-α (453.6±31pg/mL) found in the group exposed to petrol inhalation only when compared with group2 (moringa oleifera129.56±28pg/mL)} {candesartan (191.83± 46pg/mL)} and group three{captopril 92.62±23pg/mL0}was. Synthesis and secretion IL-6 interleukin 6, a cytokine is induced by TNF-α. Moringa oleifera, candesartan and captopril ameliorated the inflammation resulting from exposure to the petroleum hydrocarbon and IL6 as well as tumor necrosis factors increase that followed. TNF-α and IL6 were suspected to play a significant role in manifesting effect of petrol in the body of the Wister rats. Key words: Interlukin-6, Tumor necrotic factor -α (TNF-α), petrol, captopril, moringa oleifera