Transmembrane channel-like genes are conserved throughout various animal species including human, mouse, nematode, etc. The proteins encoded by their orthologs and paralogs appear to be present in various tissues including nerves, muscles and the heart. Recently, details in the expressions and functions of the nematode and murine paralogs have been demonstrated for example, in sensory nerves, auditory hair cells, and muscles. In this study, we investigated on one murine and one nematode paralogs both of which have been unexplored before in terms of the expression and function. Marked expressions were found in part of sensory ganglia in both of the species. The murine paralog shared locations for its expression with subpopulation markers such as a neuropeptide CGRP and an thermosensitive ion channel TRPV1. We also demonstrated that both of the paralogs are cation-permeable ion channels and that they responded to environmental stimuli with same modalities but different sensitivities.Furthermore, their knockdown partly affected somatosensory phenotypes in both of the species. The results therefore indicates that these two transmembrane proteins may share somatosensory roles despite differential responsiveness.