Voltage-gated sodium channels (NaVs) are central to cellular excitation and are important drug targets. We have determined the structure of a closed conformation of a pore only bacterial NaV (BacNaV) that provides insight into both of these fundamental properties. Our findings underscore commonalities between BacNaVs and eukaryotic voltage gated channels and provide a framework for understanding gating and ion permeation in this superfamily.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, SA293
Research Symposium: Structure of sodium channel pore – implications for ion permeation and gating
D. Minor1
1. UCSF Cardiovascular Research Institute, San Francisco, California, United States.
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Where applicable, experiments conform with Society ethical requirements.