Apical membrane chloride channel critical to the regulation of fluid, chloride and bicarbonate transport in epithelia and other cell types. Build the RSV persistent infection HBECs model. Using whole cell recording method records persistent infection with RSV people bronchial epithelium cells model control group and negative model group cells on the change of CFTR Cl. We through the method of immunofluorescence, WB and realtime-PCR test RSV continued infected cells CFTR protein levels positioning and expression. In the persistent infection with RSV people bronchial epithelium cells model control group cell membrane and negative in the cytoplasm is higher expression on CFTR.tract infection for people bronchial RSV after cells in cells, chloride ion concentrations increasing, and inhibit CFTR Cl current change, at the same time depresses their CFTR expression and function.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, PCC067
Poster Communications: Study on the function of CFTR in Human Bronchial Epithelial Cells under persistent infection by RSV
G. Gao1, X. Qin1, Y. Xiang1, C. Liu1, H. Liu1
1. Central South University, Changsha, China.
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Where applicable, experiments conform with Society ethical requirements.