We have shown previously that the concentrations of L-type Ca2+ channel blockers used during development of the voltage-sensitive release mechanism (VSRM) hypothesis, failed to exclude completely transmembrane Ca2+ entry (Griffiths & MacLeod, 2001). We formulated the hypothesis that calcium-induced calcium release (CICR) operated with increased gain under conditions necessary for the VSRM. An experiment was designed to evaluate the effect of holding potential on the gain of excitation-contraction coupling.
University College London (2003) J Physiol 547P, C76
Oral Communications: The gain of calcium-induced calcium release is set by the holding potential
H. Griffiths and K.T. MacLeod
Department of Cardiac Medicine, NHLI, Imperial College, Dovehouse Street, London SW3 6LY, UK
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Where applicable, experiments conform with Society ethical requirements.