The gut microbiota plays a crucial role in various metabolic processes such as carbohydrate fermentation, bile acid metabolism, and amino acid degradation. These processes generate metabolites and inflammatory signals that directly impact the metabolism of the host at peripheral organ sites, particularly skeletal muscle. Aging is associated with increased medication, reduced physical activity, and dietary modifications, all of which can alter the composition and metabolic activity of the gut microbiota. Consequently, the gut microbiota is implicated in several age-related diseases and conditions, including sarcopenia.

This presentation aims to provide an overview of the intricate relationship between aging and the gut microbiota. It will delve into the emerging evidence suggesting a causal connection between the gut microbiota and changes in skeletal muscle mass. Lastly, the discussion will emphasize the potential role of dietary fibre intake, known to significantly influence the composition and metabolic activity of the gut microbiota, in preventing sarcopenia.