In the IMI PharmaCog project (2010-2014) we showed that the electroencephalographic (EEG) rhythms related to eyes opening as a condition of cortical arousal are abnormal in patients with mild cognitive impairment and Alzheimer’s disease (AD; Babiloni et al., 2010, JAD). Towards a back-translation we evaluated whether EEG rhythms related to motor activity change across physiological aging in wild type (WT) mice, as well as in Tg models of AD such as PDAPP and TASTPM mice. For the physiological aging, EEG data were recorded in 19 young (4.5-6 months), 12 middle age (12-14 months), and 15 old (24 months) male WT mice. For the pathological aging, EEG data were recorded in 15 WT vs. 10 PDAPP male mice (24 months), as well as in 14 WT mice (12-14 months) vs. 15 TASTPM mice (12-14 months). Artifact-free EEG segments during wake active state (gross movements, exploratory movements or locomotor activity) and passive state (no sleep) were used as an input for EEG power density analysis. Results showed that (1) 1-2 and 2-4 Hz power density during the passive state was greater in old WT than in young and middle age WT mice (p<0.05); (2) 6-8 Hz power density during the active state was greater in these old mice (p<0.05); (3) 8-10 Hz power density during the active state was greater in young than in middle age mice (p<0.05); (4) 2-4 and 4-6 Hz power density during the passive state was lower in PDAPP compared to WT mice (p<0.05); (5) 8-10 Hz power density during the active state was lower in PDAPP compared to WT mice (p<0.05); (6) 2-4 and 4-6 Hz power density during the passive state was lower in TASTPM compared to WT mice (p<0.05); and (7) 10-12 Hz power density during the active state was lower in TASTPM compared to WT mice (p<0.05). The present results suggest that the EEG markers of motor activity are useful to unveil neurophysiological mechanisms of cortical neural synchronization characterizing the physiological aging in WT mice, as well as the pathological cortical neural synchronization in Tg mice.
37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS, SA417
Research Symposium: Translational spectral electroencephalographic markers in the European PharmaCog project: a new resource for drug discovery for Alzheimer’s disease
C. Babiloni1,2, F. Infarinato3, J. F. Bastlund4, B. Clausen4, G. Forloni5, A. Frasca5, M. Bentivoglio6, P. F. Fabene6, G. Bertini6, J. Kelley7, S. Dix8, J. C. Richardson9, W. Drinkenburg7, C. Del Percio3
1. University Sapienza, Rome, Rome, Italy. 2. University of Foggia, Foggia, Italy. 3. IRCCS San Raffaele Pisana, Roma, Italy. 4. Lundbeck, Valby, Denmark. 5. Mario Negri Institute, Milano, Italy. 6. University of Verona, Verona, Italy. 7. Janssen, Beerse, Belgium. 8. Eli Lilly, Basingstoke, United Kingdom. 9. GSK, Brentford, United Kingdom.
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Where applicable, experiments conform with Society ethical requirements.