• Tuesday 02 July - Thursday 04 July 2024

Physiology in Focus 2024

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  • Date

    Tue 02 - Thu 04 Jul 2024

  • Location

    Northumbria University, Newcastle-upon-Tyne, UK

Key Information for Delegate Arrival

Location map

Joining instructions

Online Conference Web App

Key Information for Conference Dinner

The dinner will take place on Wednesday 3 July at St James’ Park, the home of Newcastle United. Please note, this is a ticketed event.

Guests can arrive from 19:15 and will need to report to the Milburn Reception to be directed to the suite. This is located parallel to Barrack Road in the glass atrium.

St James’ Park location map

 

The Physiological Society and The Scandinavian Physiological Society look forward to welcoming you to Newcastle in July for our joint conference. 

This meeting is supported by AD Instruments, Cambridge Electronic Design, and Labtech.

Take the opportunity to hear the latest in physiology while catching up with friends and colleagues from around the world. Enjoy a warm Northern welcome with a selection of the best and most exciting in current physiological research, unmissable networking opportunities and inspiring plenary and keynote lectures. 
“The Scandinavian Physiological Society is very excited about collaborating with The Physiological Society on Physiology in Focus 2024. It makes a lot of sense for next-door neighbours to join annual meetings, particularly because our collaboration has worked really well in the past. It has actually been great fun and brought a lot of creativity into the game of arranging scientific meetings. It is our task to bring you the benefits of a broad meeting with the networking and community feel of a focus meeting. I really look forward to the work.’’ 
Professor Helle Prætorius Øhrwald (Aarhus University, Denmark), President of the Scandinavian Physiological Society
I’m delighted that we are to have a joint meeting with the Scandinavian Physiological Society. I have benefited greatly from collaborations with Scandinavian labs, and scientists from all the Scandinavian countries have made crucial contributions to our understanding of diverse physiological mechanisms. These include (with Nobel Prize dates in brackets) the Faroese-Icelander Niels Finsen’s work on phototherapy for lupus (1903), the Dane August Krogh’s proposal of capillary-level regulation of blood flow (1920), the Finn Ragnar Granit’s work on the eye (1967), the Swede Torsten Wiesel’s contribution to understanding how the brain processes visual information (1981), and the Norwegians May-Britt and Edvard Moser’s work on spatial representation within the brain (2014). I’m sure this outstanding tradition will be much in evidence at our joint meeting, and I look forward to the friendly and exciting exchange of information and ideas that will occur there.” Professor David Attwell (University College London, UK), President of The Physiological Society. 
 

Chair: Professor William Louch, Institute for Experimental Medical Research, Norway

Session 1
Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Views from Academia and Industry
10:00 Exploring cardiovascular disease, drugs and repair using human pluripotent stem cell technologies
Professor Chris Denning, University of Nottingham, UK
10:30 Pharmacological and functional differences between human iPSC-derived atrial and ventricular cardiomyocytes
Dr Steven Broadbent, Axol Bioscience, Cambridge, UK
11:00 Break
Refreshments
Session 2
New Insights into Comparative Cardiac Physiology
11:30 Temperature-induced remodelling of the turtle heart
Dr Adam Keen, Queen’s University Belfast, UK
11:50 Developmental programming of the turtle heart by hypoxia
Dr Gina Galli, University of Manchester, UK
12:10 Age-related structure in the Greenland shark heart
Professor Holly Shiels, University of Manchester, UK

Chairs: Professor Nicole Schmitt, University of Copenhagen, Denmark and Dr Dawn Davies, University of Bristol, UK

This symposium is designed for all individuals engaged or interested in the field of physiology teaching, catering to educators at every stage of their careers. Our primary objective is to cultivate a vibrant community of practice where participants can draw inspiration from the digital transformation initiatives of their peers in physiology education. We aim to provide a comprehensive understanding of generative AI technologies, such as ChatGPT, showcasing their potential to revolutionize learning activities and serve as a learning mentor for students. Attendees will have the opportunity to explore the practical applications of these tools in an educational setting, engage in hands-on sessions, and participate in discussions to address the ethical and practical dilemmas that may arise. Join us to navigate the future of digital education in physiology, enhance your teaching toolkit, and collaborate with fellow educators to shape the next generation of learning.

10:00 Introduction
Professor Nicole Schmitt, University of Copenhagen, Denmark and Dr Dawn Davies, University of Bristol, UK
10:05 Using digital escape rooms in a course on stomach, intestine and liver
Dr Ole Hartvig Mortensen, University of Copenhagen, Denmark
10:25 Suffering from lecture lethargy? Choose to break free from educational norms with escape rooms
Dr Emma Gillaspy, University of Central Lancashire, UK
10:45 Introduction to workshop
Professor Nicole Schmitt, University of Copenhagen, Denmark and Dr Dawn Davies, University of Bristol, UK
11:00 Break
Refreshments
11:30 Workshop: The new kid on the block: Generative AI. Learning opportunities and limitations of Large Language Models such as ChatGPT in teaching
Ulla Blomhøj, University of Copenhagen, Denmark
• Exploring ways to support and guide student learning using LLM/ChatGPT.
• Gaining hands-on experience with LLM/ChatGPT to create student-engaging elements.
• Getting better insight into the “art of prompting”.

Chair: Professor Henrik Dimke, University of Southern Denmark, Denmark

10:00 Introduction
Professor Henrik Dimke, University of Southern Denmark, Denmark
10:00 Comparative study of systemic and local delivery of mesenchymal stromal cells for the treatment of chronic kidney disease
Jean-Claude Kresse, Aarhus University, Denmark
10:15 Ubiquitylation of K890 in the thiazide sensitive sodium chloride cotransporter NCC is important for potassium-induced degradation of NCC
Dr Lena Rosenbæk, Aarhus University, Denmark
10:30 A novel urine pH-ammonium acid/base-score and progression of chronic kidney disease
Dr Peder Berg, Aarhus University, Denmark
10:45 Investigating novel transport mechanisms for aldosterone and the identification of putative corticosteroid transporters in the collecting duct of the kidney
Morag Milne, University of St Andrews, UK
11:00 Break
Refreshments
11:30 Male sex and age do not associate with higher kidney tissue protein abundance of ACE2 and TMPRSS2 while ACE2 is shedded into the urine in patients with COVID-19
Marie Lykke Bach, University of Southern Denmark, Denmark
11:45 Effect of Bradykinin on Renal Hemodynamics of Anesthetized Wister Rats
Professor Ahmad Ahmeda, Ajman University, United Arab Emirates
12:00 Elevated blood pressure in aged male mice with hyperaldosteronism is associated with reduced blood vessel compliance
Dr Debra Fong, Aarhus University, Denmark
12:15 Exploring the metabolic fate of adenine in adenine-induced chronic kidney disease in mice
Jasmine Atay, Aarhus University, Denmark

Chairs: Dr Irene Di Giulio, King’s College London, UK and Dr Owen Jeffries, Newcastle University, UK

10:00 Impact of operational fire exposures on firefighter health
Dr Emily Watkins, Roehampton University, London, UK
10:20 Estimating human core temperature for the prevention of occupational heat stress
Dr Hannah Marshall, Coventry University, UK
10:40 Enhancing thermoregulatory and perceptual cooling to improve performance in the heat
Dr Martin Barwood, Leeds Trinity University, UK
11:00 Break
Refreshments
11:30 Putting physiology in focus: The Physiological Society heat resilience strategy
Andrew Mackenzie, The Physiological Society, UK
12:00 Panel discussion

Chair: Dr Mia Lindskog, Uppsala University, Sweden

10:00 Engineering synaptic plasticity
Dr Onur Dagliyan, Karolinska Institutet, Sweden
10:30 Activity-dependent development of striatal connectivity
Dr Svetlana Molchanova, University of Helsinki, Finland
11:00 Break
Refreshments
11:30 Synaptic plasticity, proteome changes and astrocyte dynamics in a mouse migraine model
Dr Mai Marie Holm, Aarhus University, Denmark
11:45 Altered voltage-gated ion channel expression around drusen accumulations in induced pluripotent stem cell model of age-related macular degeneration
Molly Rowland, Northumbria University, UK
12:00 Suppressed Triose-phosphate isomerase activity affects synaptic vesicle dynamics and reduces Drosophila life span
Aelfwin Stone, University of Nottingham, UK
12:15 Intra- and inter-session reliability and repeatability of proton magnetic resonance spectroscopy for quantifying total creatine levels in multiple human brain regions
Dr Jedd Pratt, Manchester Metropolitan University, UK

Chairs: Dr Brendan Gabriel, University of Aberdeen, UK and Dr Johanna Lanner, Karolinska Institute, Sweden

10:00 Rewiring of glucose metabolism in muscle cells during hypertrophy and atrophy
Professor Juha Hulmi, University of Jyväskylä, Finland
10:30 Change of voltage-gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse model
Dr Olena Butenko, Leiden University Medical Center, The Netherlands
10:45 The impact of acute exercise before and after a simulated nightshift on metabolic health markers in healthy adults: An interim analysis of a randomised controlled trial
Cian Sweeney, Nottingham Trent University, UK
11:00 Break
Refreshments
11:30 The regulation of muscle protein metabolism by nutrition and interaction with exercise/inactivity
Professor Philip Atherton, University of Nottingham, UK
12:00 Panel discussion
All speakers

Chairs: Dr Thomas Andrew Jepps, University of Copenhagen, Denmark

10:00 Assessing the medium- and longer- term effects of vaping on the small veins and arteries of people making a stop-smoking attempt
Dr Markos Klonizakis, Sheffield Hallam University, UK
10:25 Growth and biomechanical risk progression of abdominal aortic aneurysms under serial computed tomography assessment
Dr Antti Siika, Karolinska Institutet, Sweden
10:48 Peripheral vascular adaptations to high-intensity interval training in patients with COPD
Dr Ronan Berg, University of Copenhagen, Denmark
11:00 Break
Refreshments
11:30 Liver sinusoidal endothelial cells: Super scavengers and sieve cells
Professor Karen Kristine Sørensen, UiT The Arctic University of Norway, Norway
11:55 Increased TRPV4 channel expression enhances and impairs blood flow control in hypertension
Dr Calum Wilson, University of Strathclyde, Glasgow, UK
12:18 The role of sortillin-related VPS10P containing receptor, SorCS2 in endothelial and smooth muscle cell function
Rashika Sivakumar, Aarhus University, Denmark

Join us to network and get tips on how to develop your career from those who have been there. Hear the journeys of physiologists that have transitioned to their current roles, including academic, clinical, governmental and industrial career pathways, and have the opportunity to ask questions related to your own possible paths. It’s also a prime opportunity to take advantage of meeting in small-group format with other like-minded individuals at the same career stage as you. Lunch will be provided during this session.

Facilitator:
Andrew Mackenzie, The Physiological Society, UK

Panellists:
Dr Catriona Cunningham, University of Aberdeen, UK
Dr Ifigeneia Giakoumaki, Performance Analyst for an Investment Firm, UK
Professor Ioannis Vogiatzis, Northumbria University, UK

Organisers: Dr Sjannie Lefevre, University of Oslo, Norway and Professor Tobias Wang, Aarhus University, Denmark

The skeletal muscles continuously adapt in response to usage, and the maintenance of skeletal muscle mass is crucial for health and longevity. Humans experience a gradual loss of muscle mass in prolonged physical inactivity this devastating process is aggravated in illness, recoveries from surgery, or exposure to microgravity during spaceflight. With inspiration from the “August Krogh principle”, ie that “For a wide range of problems, there will be one or a few choice animals on which it can be most conveniently studied”, this symposium stresses the potential to harness the use non-standard ”exotic” animal models and discover previously unknown, but evolutionarily conserved mechanisms of muscle mass regulation. 

15:00 SA01 Muscle mitochondrial dysfunction in astronauts during spaceflight. What we can learn from and about the space environment
Professor Marta Murgia, University of Padova, Italy
15:30 SA02 Extreme postprandial muscle growth in a sedentary ectotherm: Gut-derived humoral signals trigger a rapid postprandial anabolic response in the digesting Burmese python
Dr Emil Rindom, Aarhus University, Denmark
15:45 SA03 Harnessing the gut microbiota to facilitate muscle protein synthesis during fasting hibernation
Dr Matthew Regan, University of Montréal, Canada
16:00 SA04 Muscle preservation during bear hibernation
Professor Fabrice Bertile, University of Strasbourg

Organiser: Professor Michael Taggart, Newcastle University, UK

Human pregnancy presents an astonishing number of physiological challenges at molecular, cellular, organ and organism levels and a successful pregnancy outcome – the safe delivery of a healthy baby and placenta at term – is critically dependent upon appropriate remodelling events.  This is particularly evident for changes occurring at the maternal-placental-fetal interface throughout gestation.  This symposium brings together experts undertaking cutting-edge research to understand the fundamental physiological processes of human uteroplacental remodelling in normal pregnancy and how these may be impacted by situations of complicated pregnancies.  Topics to be covered include maternal-placental circulatory homeostasis, molecular regulation of trophoblast invasion, molecular/cellular mapping of the uterine organ and clinical strategies to avert poor outcomes in situations of aberrant placentation.

15:00 SA05 Two circulations, one goal: Matched haemodynamics at the maternal-placental interface
Professor Lopa Leach, University of Nottingham, UK
15:30 SA06 Retroviral transposable elements and the pregnancy remodelling functions of human trophoblast
Dr Jennifer Frost, King's College London, UK
15:45 SA07 Multi-omic mapping of the human myometrium and decidua to decipher spontaneous labour
Dr Pei Lai, Imperial College London, UK
16:00 The placenta accreta spectrum
Professor Steve Robson, Newcastle University, UK

Organiser: Professor Charlotte Haigh, University of Leeds, UK

This symposium will address research about sense of belonging and increased motivation for learning. Sense of belonging is one of the most significant factors in students’ success and retention. It is something highly valued but rather hard to quantify. Despite its clear importance, many students across the sector report not feeling part of a community. In this symposium we will hear from 3 different institutions across the UK, where students study physiology and learn about initiatives used to further understand what contributes to a students’ feeling of their sense of belonging to the University but also their courses and physiology. 

15:00 SA11 Focusing on belonging in curriculum design
Professor Charlotte Haigh, University of Leeds, UK
15:30 SA09 Enhancing belonging with programme-level synoptic assessment
Dr Clare Tweedy, University of Leeds, UK
15:45 SA10 The 'what' and 'why' of undergraduate physiology - student motivations for specialising in the science of life
Dr Harley Stevenson-Cocks and Martyna Fugiel, Newcastle University, UK
16:00 SA08 The importance of developing a sense of student belonging for success and progression at university
Dr Wendy Leadbeater, University of Birmingham, UK

Chairs: Dr Stephen Keely, Royal College of Surgeons in Ireland, Ireland and Professor Henrik Dimke, University of Southern Denmark, Denmark

15:00 C25 Regulation of the NaCl cotransporter NCC and blood pressure by the ubiquitin E3 ligase CHIP
Dr Mariavittoria D'Acierno, Aarhus University, Denmark
15:15 C26 Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra
Dr Bernard Drumm, Dundalk Institute of Technology, Ireland
15:30 C27 Maternal, paternal and combined parental obesity impact fetal growth via parent-specific and combined effects on placental morphology and transport function
Sachi Gwalani, University of Cambridge, UK
15:45 C28 E. coli Nissle improves short-chain fatty acid absorption, microbial composition, and gut barrier function in the inflamed cecum of slc26a3−/− mice
Professor Ursula Seidler, Hannover Medical School, Germany
16:00 C29 The antimicrobial peptide cathelicidin gates the bacterial survival in urine from newly renal transplanted recipients
Laura Sparsø, Aarhus University, Denmark
16:15 C30 The role of aquaporin-2 in cyst progression in autosomal dominant polycystic kidney disease
Vishalini Venkatesan, University of Copenhagen, Denmark

Chairs: Professor Catherine Hall, University of Sussex, UK and Dr Mai Marie Holm, Aarhus University, Denmark

15:00 C48 Retinal cone-driven responses to flickering stimuli recorded from over 2000 adults: associations with age, sex and ethnicity
Hamza Ahmed, University College London, UK
15:15 C49 The impact of fatiguing exercise on corticospinal function in relapse-remitting multiple sclerosis
Gemma Brownbill, Brighton and Sussex Medical School, UK
15:30 C50 The human taste code
Professor Göran Hellekant, University of Minnesota Duluth, US
15:45 C51 Chronic vagus nerve stimulation reduces muscle sympathetic nerve activity in drug-resistant epilepsy
Professor Vaughan Macefield, Monash University, Australia
16:00 C52 The loss of Ca2+ -activated Cl- channel, TMEM16A worsens the ischemic stroke-reperfusion outcome
Elizaveta Melnikova, Aarhus University, Denmark
16:15 C53 G155D mutation associated with autosomal dominant nocturnal frontal lobe epilepsy alters the structure-function relationship of calcium binding protein 4
Vanessa Morris, University of Liverpool, UK

Organisers: Dr Fatima Perez de Heredia, Liverpool John Moores University, UK and Dr Adrian O’Hara, Liverpool John Moores University, UK

The adipose tissue is a main endocrine and metabolic regulator, and new avenues of research are producing exciting evidence to help us understand the physiological traits predisposing to different degrees of metabolic disturbance associated with obesity, the presence of healthy and unhealthy obesity phenotypes, or the cycles of body weight loss and regain, beyond or in addition to behavioural and environmental factors. 

This symposium will delve into the physiology of adipose tissue and how it communicates with different organs in the body, such as skeletal muscle, the central nervous system, or the digestive system, and with the environment  through its circadian regulation. 

10:00 SA12 Bidirectional metabokine and lipokine-mediated adipose tissue: Skeletal muscle crosstalk during browning of adipose tissue
Professor Lee Roberts, University of Leeds, UK
10:30 SA13 Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes
Peter Yitao Zhu, University of Oxford, UK
10:45 SA14 Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways
Maria Rodriguez Martin, University of Murcia, Spain
11:00 Metabolically healthy and unhealthy obesity and cardiometabolic health
Professor Dan Cuthbertson, University of Liverpool, UK

Organiser: Dr Mia Lindskog, Uppsala University, Sweden

A healthy brain is a brain in balance, but being in balance is far from being static. Keeping the neuronal activity within a range while allowing for increased activity in specific pathways, for example during learning, is fundamental to healthy brain function. Several synaptic mechanisms have been described to mediate the balance in neuronal networks, where the most prominent are synaptic plasticity, allowing regulation of individual synapses in response to synchronous activity, and synaptic homeostasis where synapses are collectively up or down regulated to keep the overall activity in the network balanced. This session will explore how physiological processes regulate different forms of plasticity and the role of plasticity for shaping context relevant behavior or emotions.

10:00 Spike timing precision underlying brain plasticity and oscillations during development and the progression of Alzheimer's disease.
Yuniesky Andrade Talavera, Universidad Pablo de Olavide, Spain
10:20 PCB066 Using a mouse model of Alzheimer's disease to unravel early pathological neurovascular changes preceding cognitive decline
Harry Trewhitt, University of Sussex, UK
10:40 SA15 Esr1+ hypothalamic-habenula neurons shape aversive states
Dr Daniela Calvigioni, Karolinska Institutet, Sweden
11:00 Innate fear learning requires dopaminergic activation of astrocytes in the anterior cingulate cortex
Professor Thomas Nevian, Bern University, Switzerland

Organisers: Dr Fiona McBryde, University of Auckland, New Zealand and Professor Julian Paton, University of Auckland, New Zealand

Despite containing the majority (60%) of blood volume at rest, the venous circulation has largely been overlooked when exploring cardiovascular therapeutics. Exciting recent research has revolutionized our understanding of how the veins interact with the sympathetic nervous system and adjust to physiological challenges, how venous function may become perturbed in hypertension and how we may be able to model and selectively target venous compliance in order to alleviate cardiovascular disease.

10:00 Unveiling the role of the venous system in arterial hypertension: A computational study
Professor Eleuterio Toro, University of Trento, Italy
10:30 SA16 The Forgotten Circulation: Reduced mesenteric venous capacitance in hypertensive rats is improved by decreasing sympathetic activity
Dr Tonja Emans, University of Auckland, New Zealand
10:45 Retrograde blood flow in the internal jugular veins of humans with hypertension: Implications for cerebral arterial blood flow
Dr Emma Hart, University of Bristol, UK
11:00 SA17 The elusive but large role of the venous system in vasovagal syncope and orthostatic hypotension
Professor Gert van Dijk, Leiden University Medical Center, The Netherlands

Chairs: Dr Mike Gray, Newcastle University, UK and Dr Lena Rosenbaek, Aarhus University, Denmark

10:00 C31 Adenine-induced kidney disease: an animal model to study uremic toxins
Søren Elsborg, Aarhus University, Denmark
10:15 C32 Species differences in renal response to the bile acid lithocholic acid
Sandra Hansen, Aarhus University, Denmark
10:30 C33 Acute thrombocyte-dependent clearance of Escherichia coli requires D-mannose-sites for bacterial adherence
Emil Herrig Lambertsen, Aarhus University, Denmark
10:45 C34 The SGLT-2 inhibitor empagliflozin reduces intrarenal complement activation in patients with diabetes and chronic kidney disease
Mia Jensen, University of Southern Denmark, Denmark
11:00 C35 The secondary bile acid, lithocholic acid, exerts anti-secretory actions in colonic epithelial cells in vitro
Dr Stephen Keely, Royal College of Surgeons in Ireland, Dublin, Ireland

Chairs:Dr Luke Hughes, Northumbria University and Dr Johanna Lanner, Karolinksa Institute, Sweden

10:00 C36 Induction of ATF4-regulated atrogenes is uncoupled from muscle atrophy during disuse in halofuginone-treated mice and in hibernating brown bears
Dr Lydie Combaret, French National Research Institute for Agriculture, Food and Environment, Paris, France
10:15 C37 Neurovascular coupling during dynamic upper body resistance exercise in healthy individuals
Stephanie Korad, Massey University, New Zealand
10:30 C38 Comparison of ectopic fat deposition between children with and without obesity: Influence of sex and physical activity level
Dr Ryan Larsen, Aalborg University, Denmark
10:45 C39 High-intensity continuous exercise elevates I-FABP2 levels equally across 30 and 60-minute durations in healthy males
Dr Lewis Mattin, University of Westminster, UK
11:00 C40 The impact of chronic electronic cigarette use on blood pressure responses to exercise
Maddie Roscoe, University of Bristol, UK
11:15 C46 Insights into the transforming growth factor superfamily specific modulation: Unravelling the impact of hibernating bear serum in primary human muscle cells
Chloé Richard, National Research Institute for Agriculture, Food and the Environment, Paris, France

Join us to share innovative approaches to teaching, including how to integrate playful and artistic learning techniques into your teaching. Learning outcomes include:

  1. Understand different methodologies to teach Physiological concepts
  2. Understand the creative journeys into deciding on innovative ways of teaching
  3. How to implement these methodologies within your own teaching
  4. How to evaluate the use of these methodologies to ensure student understanding=

Chair:
Professor Matthew Mason, University of Cambridge, UK

Speaker panel:
Dr Francesca Arrigoni, Kingston University, UK
Dr Sara Namvar, University of Salford, UK
Dr Nicole Schmitt, University of Copenhagen, Denmark

All contributors will also be available following the session for demonstrations and/or tutorials. This will be from 13:30-14:30 on Wednesday 3 July.

This session is designed to enlighten you to the mutual benefits of industry-academic partnerships to both your own academic work and the industrial partners. Join us to hear from those who have established successful industry-academic partnerships with global corporates in the areas of sportwear and healthcare products, as well as those working in the clinical physiology space, with their own start-up journey and patents under their belts.

Chair:
Dr Davide Filingeri, University of Southampton, UK

Speaker panel:
Dr Peder Berg, University of Aarhus, Denmark
Rob Gathercole, Lululemon, Canada (virtual contribution)
Prof Jens Leipziger, University of Aarhus, Denmark

Do you want to be more successful in acquiring grant funding?

Join us to learn from those who have had successful submissions as they share examples of best practice in applying, and also the learnings from their unsuccessful applications. The session will also provide first-hand advice from members of grant review panels, shedding insight onto the common pitfalls, and tips to enhance chances of success. You may also find a community of researchers interested in submitting applications within this realm who are open to collaborations.

Chair:
Professor Helle Prætorius Øhrwald, Aarhus University, Denmark

Speaker panel:
Professor Deborah Baines, St George’s University London, UK
Dr Matthew Brook, University of Nottingham, UK
Dr Luke Hughes, Northumbria University, UK

Organisers: Professor Stuart Phillips, McMaster University, Hamilton, Canada and Professor Philip Atherton, University of Nottingham, UK 

The symposium will showcase how “bench-to-bedside” research in two organ systems – brain and skeletal muscle – has furthered our understanding of the metabolic and molecular mechanisms underpinning age-associated declines in these tissues and contributed to developing mitigation strategies. The importance of this symposium is highlighted by the fact that we have no pharmacological means to slow either muscle or brain aging effectively. Hence, an emphasis in this symposium is on lifestyle – physical activity and nutritional – means by which we can offer strategies to maximize their lifespan and their health span.

14:30 SA18 Use it or lose it: the importance of contractile activity for maintenance of skeletal muscle mass and function in older age
Professor Bethan Phillips, University of Nottingham, UK
15:00 SA19 Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
Dr Grith Stougaard Hoejfeldt, University of Copenhagen, Denmark
15:15 SA20 Acute effects of exercise on brain metabolites and cognition in older adults
Dr Naiara Demnitz, University of Copenhagen, Denmark
15:30 SA21 Mind the Brain: Powering your brain through exercise and diet
Professor Carl-Johan Boraxbekk, University of Copenhagen, Denmark

Organiser: Professor Russell Hepple, University of Florida, Gainesville, US

Mitochondrial permeability transition (mPT) is triggered in response to excessive mitochondrial matrix Ca2+ that opens a non-specific pore (mPT pore) across the mitochondrial inner membrane. mPT is associated with bioenergetic decline, and causes the release of various mitochondrial constituents that can activate proteolytic/apoptotic/necroptotic and inflammatory pathways (e.g., via release of cytochrome c, mitochondrial DNA). This symposium will provide an overview of the events surrounding mPT and their cellular consequences, and discuss: novel techniques for studying mPT, the role of the mitochondrial calcium uniporter in mPT in heart failure, and the role of mPT in driving skeletal muscle pathology. 

14:30 SA22 Contribution(s) of the permeability transition pore to the pathophysiology of Vici syndrome, a severe multisystem disorder of childhood
Professor Michael Duchen, University College London, UK
15:00 SA23 Electrophysiological properties of the inner mitochondrial membrane: diversity of mechanisms of mitochondrial dysfunction
Dr Maria Neginskaya, Albert Einstein University, New York City, US
15:15 SA24 The interplay between mitochondrial calcium, permeability transition, and cell death in cardiac maladaptation to chronic stress
Dr Joanne Garbincius, Temple University, Philadelphia, US
15:30 SA25 Emerging role of mPT in driving atrophy, mitochondrial dysfunction and denervation in skeletal muscle with aging and disease
Dr Russell Hepple, University of Florida, Gainesville, US

Organisers: Professor Kim E. Barrett, University of California, Davis, US and Dr Stephen J. Keely, Royal College of Surgeons in Ireland, Dublin, Ireland

Obesity has reached epidemic proportions worldwide, with unsustainable impacts on health and healthcare budgets and fueling a search for more effective therapies.  The current/emerging armamentarium beyond lifestyle changes includes bariatric surgery, new pharmacological treatments such as glucagon-like peptide-1 agonists, and specialized dietary approaches, with the efficacy of all of these involving a role for the gastrointestinal tract and/or its microbiome.  The symposium will address basic alimentary physiology and brain-gut interactions in the context of anti-obesity treatments, which may inform new research directions and avenues for new therapeutic approaches.

14:30 SA26 Using the gut brain axis to improve obesity treatment
Professor Carel le Roux, University College Dublin, Ireland
15:00 SA27 TGR5-dependent host-microbiome interactions reestablish epithelial intestinal homeostasis following colon injury
Dr Alessia Perino, Ecole Polytechnique Fédérale de Lausanne, Switzerland
15:15 SA28 Exploring fructose kinetics in Type 2 Diabetes: preliminary data from the ERIE trial
Florine Westerbeke, Amsterdam University Medical Center, The Netherlands
15:30 SA29 The gut-brain GLP-1 axis: role in limiting nutrient uptake and countering obesity
Professor Fiona Gribble, University of Cambridge, UK

Chairs: Dr Daniel Brayson, University of Westminster, UK and Professor Anne K D Hafstad, The Arctic University of Norway, Norway

14:30 C01 Hepatocyte-specific deletion of HIF2α is associated with basal dysfunction, but protection against Western diet induced sympathetic dominance in the mouse heart
Lorenz Holzner, University of Cambridge, UK
14:45 C02 Thrombocytes constitutes an efficient clearance system for uropathogenic Escherichia coli in a murine urosepsis model
Nanna Johnsen, Aarhus University, Denmark
15:00 C03 High-fat diet blunts the carotid body mediated-ventilatory effects of TNF-α
Gonçalo Melo, NOVA Medical School, Lisbon, Portugal
15:15 C04 The effects of water temperature and immersion depth on shear stress, arterial dilation, and flow-mediated dilation following heating
Campbell Menzies, Coventry University, UK
15:30 C05 Cerebral pulsatility index in a mouse model of acute ischemic stroke
Christina Shen-Zhuang Nielsen, Aarhus University, Denmark
15:45 C06 Novel Dbh+ catecholaminergic cardiomyocytes contributing to the structure and function of the cardiac conduction system in murine heart
Dr Tianyi Sun, University of Oxford, UK

Chairs: Dr Alison Howard, Newcastle University, UK and Dr Ole Hartvig Mortensen, University of Copenhagen, Denmark

14:30 C13 Teamwork, proposal writing, and application-style assignments prepare undergraduates for research and science-related careers
Dr Michelle French, University of Toronto, Canada
14:45 C14 Cheating or Not Cheating? A workflow for including critical appraisal when writing paragraphs using a large language model.
Dr Matt Hardy, University of Bradford, UK
15:00 C15 Ten years of worms: Development of an 'earthworm action potentials' practical class
Professor Matthew Mason, University of Cambridge, UK
15:15 C16 Investigating action potential conduction velocity supernormality in earthworm giant fibres as a student project
Dr James Fraser, University of Cambridge, UK
15:30 C17 Decolonising the curriculum: healthcare inequalities faced by Gypsy, Traveller, Roma, Showmen and Boater Communities
Emilie Puttová, University of Aberdeen, UK
15:45 C18 The Importance of re-establishing group work in post-covid physiology laboratory team activities
Dr Elizabeth Sheader and Dr Michelle Keown, University of Manchester, UK

Organisers: Dr Brendan Gabriel, University of Aberdeen, UK and Professor Alexandra Johnstone, University of Aberdeen, UK

This symposium aims to explore the profound impact of circadian rhythms on human physiology and its relevance to various disease states. The circadian system, governed by an intrinsic biological clock, orchestrates a wide array of physiological processes, including hormone secretion, metabolism, and cognitive functions. Recent advancements in circadian biology have elucidated the intricate mechanisms underlying these rhythms and their crucial role in maintaining health. This symposium will provide a platform for leading experts and early career researchers in the field to discuss the latest scientific findings, exchange knowledge, and delve into the implications of circadian physiology on human well-being.

10:00 SA30 Time-of-day dependent metabolic response to exercise
Professor Juleen Zierath, Karolinska Institute, Stockholm, Sweden
10:30 SA31 Optimising concomitant metformin and exercise treatment by precision timing to improve glycaemic regulation in people with type 2 diabetes
Brenda Pena Carrillo, University of Aberdeen, UK
10:45 SA32 The complexities of characterising shift work, diet and blood glucose variability in a real-world setting
Dr Rachel Gibson, King's College London, UK
11:00 SA33 Examining the contribution of NR1D1 to adaptive metabolic response
Prof David Bechtold, University of Manchester, UK

Organisers: Professor Vladimir Matchkov, Aarhus University, Denmark and Dr Dmitry Postnov, Aarhus University, Denmark 

The brain function needs to be studied considering a match of local blood supply to neuronal activity, and its significance for majority of neuronal disorders. Recent progress in the field empowered our understanding of this neurovascular control and its changes in severe pathologies, such as Alzheimer disease and stroke, thanks to advantages made in in vivo imaging techniques, spatial omics, and molecular biology. This progress goes to drawing new details with cell-type specific resolution of molecular signaling pathways involved and to the role of spatial and temporal dynamics of cerebral blood flow. The proposed symposium aims celebrate this progress.

10:00 SA34 Reversing pericyte-mediated capillary constriction: A therapeutic target for restoring cerebral blood flow in dementia-causing conditions
Professor David Attwell, University College London, UK
10:30 SA35 Lasting, low amplitude responses characterize the remodeled neurovascular coupling and Ca2+ signaling in the aged awake mouse brain
Dr Changsi Cai, University of Copenhagen, Denmark
10:50 SA36 Capturing rapid changes in cerebral blood flow
Dr Dmitry Postnov, Aarhus University, Denmark
11:10 SA37 Neurovascular impulse response function, neuromodulation and behavior
Bradley Rauscher, University of Boston, US

Organisers: Professor Jens Leipziger, Aarhus University, Denmark and Professor Helle Prætorius, Aarhus University, Denmark 

Chairs: Professor Jens Leipziger, Aarhus University, Denmark and Dr Mike Gray, Newcastle University, UK

Gastrointestinal hormones comprise a large group of peptides that regulate the digestive and metabolic processes during the different phases of food uptake and handling. Peptide hormones elicit their effects via their specific G-protein-coupled receptors. Several gastrointestinal peptide hormone receptors are found in the kidney and recent results indicate highly new and key functional effect to GI hormones on the function of the kidney. The bigger theme is the gut kidney axis that tries to uncover the multiple influences by which the signals from the gastrointestinal system influence the kidneys. This symposium suggestion attempts to be specific by focusing on hormone signals only. These hormones comprise glucagon, secretin and ghrelin. 

10:00 SA39 Transcriptomics and proteomics data from micro-dissected renal tubules identifies the distributions of all GPCRs along the renal tubule
Professor Mark Knepper, NIH, US
10:25 SA38 Direct activation of renal, Ghrelin-family GPR39 receptors reduces urinary concentration capacity
Professor Helle Prætorius Øhrwald, Aarhus University, Denmark
10:40 SA40 Secretin: a key regulator of urine production and acid/base excretion
Dr Peder Berg, Aarhus University, Denmark
10:55 SA41 Physiological quantification of GI hormones and their mechanisms of release
Dr Katrine Douglas Galsgaard, University of Copenhagen, Denmark
11:10 SA42 The effects of glucagon on the kidney distal convoluted tubule and blood pressure
Professor Robert Fenton, Aarhus University, Denmark

Chairs: Professor Nicole Schmitt, University of Copenhagen, Denmark and Dr Harley Stevenson-Cocks, Newcastle University, UK

10:15 C20 A students as partners approach to developing online interactive physiology content
Dr Catriona Cunningham, University of Aberdeen, UK
10:30 C21 Evaluating the implementation of online exam proctoring on physiology module attainment and student experience
Dr Matthew Jones, University of Salford, UK
10:45 C22 The use of 'hospital ward' clinical simulations and escape games to enhance career development for physiology students studying life sciences courses
Dr Sara Namwar, University of Salford, UK
11:00 C23 Comparison of undergraduate science student evaluation of skills confidence before and after objective structured practical examinations (OSPEs)
Professor Derek Scott, University of Aberdeen, UK
11:15 C24 Rubric-based assessment of flipped classroom presentations: A marker's perspective
Dr Marta Woloszynowska-Fraser, Keele University, UK

Chairs: Dr Gerrit Hilgen, Northumbria University, UK and Dr Svetlana Molchanova, University of Helsinki, Finland

10:00 C58 Identification of novel APOE4-induced impairments to action potential firing in murine CA1 pyramidal neurons and associated rescue with clinically relevant NMDAR antagonists
Nicoleta Stegarescu, Brighton and Sussex Medical School, UK
10:15 C55 Expiratory muscle activation pattern during exposure to hypoxia and hypercapnia
Daniel Breseghello Zoccal, São Paulo State University, Brazil
10:30 C56 Unveiling the unseen: An in-depth exploration of fetal brain metabolism with magnetic resonance spectroscopy
Jordan Arthur Minns, University of South Australia, Australia
10:45 C57 Vastus medialis activation and knee extensor neuromuscular function across the menstrual cycle
Elisa Nédélec, Nottingham Trent University, UK
11:00 C54 The influence of the menopause and hormone replacement therapy on cortical neuroplasticity
Dr Paul Ansdell, Northumbria University, UK
11:15 C59 Assessment of olfactory response to social and non-social cues in valproic acid induced rat model of autism
Dr Süeda Tunçak, Bursa Uludağ University, Turkey

Organisers: Professor Brian Harvey, Royal College of Surgeons in Ireland, Dublin, Ireland and Professor Pernille Laerkegaard Hansen, University of Southern Denmark, Odense, Denmark 

The physiological role of the Aldosterone (Aldo) and Mineralocorticoid Receptor (MR) endocrine system (Aldo/MR) is the regulation of renal sodium balance. In the last two decades, biological effects of Aldo/MR have been reported in multiple organs such as heart, vasculature, and adipose tissue. Chronic activation of Aldo/MR is associated with cardiovascular disease (CVD), Metabolic Syndrome (MetS) and Type 2 Diabetes (T2D) which are classified as comorbid diseases. The Aldo/MR Comorbidity Symposium will address four hot topics: Aldo/MR therapeutic targeting, epigenetics and transcriptional regulation, Aldo/MR in MetS and T2D, Aldo/MR in immune cells and Aldo/MR in hyperaldosteronism and CVD. 

13:30 SA43 Aldo/MR therapeutic targeting, epigenetics and transcriptional regulation
Dr Achim Lother, Freiburg University, Germany
14:00 SA44 Expression of functional mineralocorticoid receptor (MR) and G-protein coupled estrogen receptor (GPER) in human T lymphocytes
Dr Maria Piazza, University of Padua, Italy
14:15 SA45 Cardiometabolic consequences of adrenal gland dysfunction
Dr Sheerazed Boulkroun, PARCC, INSERM, Paris, France
14:30 SA46 Mineralocorticoid receptors in metabolic syndrome
Professor Massimiliano Caprio, San Raffaele Roma Open University, Italy

Organisers: Dr Ruoli Chen, Keele University, UK and Dr Mark Dallas, University of Reading, UK

Hypoxia is a state where oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis. The responses of the tissue to hypoxia include accumulation of hypoxia inducible factors (HIFs), which are a master regulator of hypoxia and upregulate hundreds of human genes. Hypoxia can be either a cause or a consequence of some brain diseases. The aims of the proposed symposium are to discuss the role of HIF in brain homeostasis and diseases, and to explore whether pharmacological modulation of HIF can be used for treatment of brain diseases, where hypoxia is a significant contributor. 

13:30 SA47 Hypoxia-inducible factors and brain metabolism: adaptation and pathology
Professor Andrew Murray, University of Cambridge, UK
14:00 SA48 A study of hypoxia and innate immune mechanisms in experimental autoimmune optic neuritis
Dr Helen Yang, University College London, UK
14:15 SA49 Exploring the effect of hypoxia (1% O2) on the neuroinflammatory activity of mouse primary microglial cells and microglial cell line (BV-2 cells) under Lipopolysaccharide (LPS) induced inflammatory stimulation
John Bennett, Keele University, UK
14:30 SA50 Hypoxia signalling in vascular dementia
Dr Tracy Farr, University of Nottingham, UK

Organiser: Dr Conor McClenaghan, Rutgers, The State University of New Jersey, US

ATP-sensitive potassium (KATP) channels regulate electrical behaviour in a wide range of tissues – coupling cellular metabolism with membrane excitability. Through recent advances, new roles for KATP channels in physiological processes and new applications for KATP targeting therapies are emerging. This symposium will reveal novel insights into KATP channel structure-function, mechanisms of cellular trafficking, molecular pharmacology, newly described roles in cerebrovascular function, and pathophysiological consequences of KATP dysfunction in rare channelopathies, and migraine and headache disorders. 

13:30 SA51 the role of ATP-sensitive potassium channels in migraine pathogenesis
Professor Messoud Ashina, Copenhagen University Hospital Rigshospitalet-Glostrup, Denmark
14:00 SA52 New insights to KATP cardiovascular and skeletal muscle channelopathies
Dr Conor McClenaghan, Rutgers, The State University of New Jersey, US
14:15 SA53 Impaired electro-metabolic signaling in capillary pericytes disrupts hemodynamic control in aging and Alzheimer's disease
Dr Ashwini Hariharan, University of Maryland, Baltimore, US
14:30 SA54 KATP channel trafficking regulation in pancreatic β-cells
Professor Show-Ling Shyng, Oregon Health & Science University, Portland, US

Chairs: Dr Nordine Helassa, University of Liverpool, UK and Dr Christian Staehr, Aarhus University, Denmark

13:30 C07 P2X3 antagonists as a novel anti-arrhythmic
Dr Carol Bussey, University of Auckland, New Zealand
13:45 C08 The Na,K-ATPase-dependent Ca2+-sensitization by cSrc kinase in murine middle cerebral arteries is partially independent of the Rho kinase pathway
Ask Carit Andersen, Aarhus University, Denmark
14:00 C09 The differential pro-contractile effect of ouabain depends on agonist and smooth muscle activation state.
Anna Giné, Aarhus University, Denmark
14:15 C10 Evaluating the impact of succinate on cardiac electrical integrity in the mouse
Dr Andrew Holmes, University of Birmingham, UK
14:30 C11 The effect of interrupting prolonged sitting with light movement on central and peripheral haemodynamics in long covid
Nicholas Hudson, University of Winchester, UK
14:45 C12 Raising the bar on health: Can one year of endurance exercise training enhance vascular function in healthy individuals?
Marcos Paulo Rocha Alves, University of Copenhagen, Denmark

Chairs: Dr Paul Ansdell, Northumbria University, UK and Dr Rasmus Kopp, Aalborg University, Denmark

13:30 C42 Iron-catalysed free radical formation underpins the systemic vasculopathic complications in chronic mountain sickness
Professor Damian Bailey, University of South Wales, UK
13:45 C43 The role of neural input and microvascular blood flow as mediators of neuromuscular control
Dr Eleanor Jones, University of Nottingham, UK
14:00 C44 Influence of cardiorespiratory fitness on RPE and playerload in simulated mixed martial arts bouts
Dr Christopher Kirk, Sheffield Hallam University, UK
14:15 C45 Metformin inhibits glucose-uptake regulating transcription factor NR4A3 expression after exercise
Brenda J. Peña Carrillo, University of Aberdeen, UK
14:30 C41 Characterising the cellular physiology of a novel phospholipase target in skeletal muscle within the aetiologies of obesity and diabetes
Rashmi Sivasengh, University of Aberdeen, UK
14:45 C47 The role of extracellular matrix components in determining skeletal muscle fiber types: An investigation with C2C12 myoblasts
Yhusi Karina Riskawati, Taipei Medical University, Taiwan

Registration

Registration is now closed. Onsite registration will be available at the registration desk.

The conference dinner is now sold out. To be added to the waiting list, please come to the registration desk during the conference from 14:30 on Tuesday, 2 July.

Registration rates:

Membership category Early registration until 31 May 2024 Standard registration rate
until 11 June 2024
Undergraduate member rate: TPS Undergraduate & Master’s Member or SPS Student Member (if an undergraduate) £70.00 £110.00
Early Career member rate: TPS Postgraduate Member or Full Member (concessionary)* or SPS Student Member £140.00 £215.00
Member rate: TPS Full Member or Fellow Member or SPS Ordinary Member or Associate Member £200.00 £300.00
Honorary Member (TPS or SPS) £125.00 £225.00
Retired Member £125.00 £225.00
Non-Member £400.00 £500.00
ECR Non-Member* £300.00 £400.00
Conference Dinner £60.00 £60.00
Accompanying Person**  £75.00 £75.00

*please email events@physoc.org for the appropriate discount code.

**you are able to book an accompanying person during the registration process. Please email events@physoc.org to confirm the accompanying person’s name and any dietary/access requirements.

Please note, Full Member (concessionary) refers to those who have Full Membership at the reduced rate.

SPS members will need to email events@physoc.org to receive the appropriate discount code for their membership category.

Before registering, please read our event terms and conditions.

TPS Member registration

In order to register as a TPS member, you first need to log in with username and password. The system will default to the correct fee for your membership category.

Should you have any queries, please email events@physoc.org

SPS Member registration

In order to register as an SPS member, you need to email events@physoc.org to receive the appropriate discount code for your membership category. You will then need to create a guest account.

Non-member registration

In order to register as a non-member you need to create a guest account. By joining as a member, you will benefit from reduced registration and other key member benefits including:

  • Free online access to The Society’s three world-class journals
  • Free or discounted registration for Society events
  • Eligibility for Society’s grant schemes

To find out more about membership with The Society, please click here or email membership@physoc.org

Applying for a visa

Do you need a visa to be able to participate in the meeting?

To check whether you need a visa to be able to attend, please click here

For more detailed information, application forms and guidance notes, please visit the official UK visa website.

It is recommended that you apply for your visa well in advance (at least 12 weeks before the meeting) as applications for UK visas in certain countries can take longer than expected. Attendees are requested that they book early enough and apply for a visa with sufficient time prior to the conference.

The conference organisers cannot be held responsible if delegates do not receive their visas in time, and the cancellation policy will automatically apply. Every effort will be made to support genuine applications. The conference organisers are happy to provide you with documentation to support your application which will be sent as a PDF attachment. If you require a hard copy to be sent to you, please include your mailing (postal) address. The Physiological Society will only send via regular post.

Documentation to support visa applications will only be provided to those attendees who have registered to attend.

Please complete the webform below, and attach confirmation of your registration, and submitted abstract (if appropriate).

Supporting documentation will be distributed within 10 working days – it is the responsibility of the attendee to allow sufficient time for processing.

Please note that The Society are not involved with and cannot influence consular decisions.

Click here for the visa supporting documents form

Key information

Key dates

Registration opens 1 February 2024
Abstract submission opens 1 March 2024
Abstract submission closes 11 April 2024
Early review deadline 15 March 2024
Early bird registration deadline 31 May 2024
Conference Attendance Award deadline 31 May 2024
Registration deadline 11 June 2024
Meeting dates 2-4 July 2024

Venue

The meeting will take place at Northumbria University, Newcastle-upon-Tyne, UK:

Address: Business & Law Building, Northumbria University, City Campus East, Newcastle upon Tyne, NE1 8ST

Note: Please use the map below for directions to the specific venue.

Travel

By train

Direct rail services run from many UK cities to Newcastle Central Station, which is located in the heart of the city centre with its own Metro station. Newcastle is 2 hours 45 minutes from central London and 1 hour 30 minutes from Edinburgh and Leeds. Visit the National Rail website to plan your journey.

For your onward journey to the venue, you can use either the Metro, a bus or a 25 minute walk.

By Metro

The two nearest Metro stations to the Business & Law Building include Manor Metro Station (3-5 minutes walk), Monument Metro Station (7 minute walk). Visit the Nexus Metro website for more information.

By bus

Local buses: From Central Station bus stop H, take the number 62 bus to New Bridge Street, which is a 2 minute walk for the Business & Law Building.

National buses: Newcastle can be accessed from various UK cities via National Express or Mega Bus.

By air

The nearest airport is Newcastle International Airport. It is connected to the city via the Metro Light Rail system and a journey into Newcastle city centre takes approximately 20 minutes.

Other nearby airports include Leeds Bradford, Edinburgh and Manchester.

Accommodation

We do not have a specific conference hotel so attendees are able to choose accommodation which meets their needs and budgets. There are many hotels available in the city centre including those found here.

Support to Attend

Grants for Carers

We care because you do. We are aware that many of our members have caring responsibilities or need care. We have funds allocated to help you with care costs to facilitate your attendance at meetings.

Find out more

 

Conference Attendance Award

Up to £375 for the support of member engagement at our own meetings. The deadline for this meeting is 31 May 2024.

Find out more

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